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{
    "metadata": {
        "accession": "A0A2K6G3T0",
        "id": "A0A2K6G3T0_PROCO",
        "source_organism": {
            "taxId": "379532",
            "scientificName": "Propithecus coquereli",
            "fullName": "Propithecus coquereli (Coquerel's sifaka)"
        },
        "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1",
        "description": [
            "Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits"
        ],
        "length": 504,
        "sequence": "MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTETHPPEDNWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHTEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKVLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHGDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAPSAPTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP",
        "proteome": "UP000233160",
        "gene": "TAB1",
        "go_terms": [
            {
                "identifier": "GO:0004722",
                "name": "protein serine/threonine phosphatase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006470",
                "name": "protein dephosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "9761dfa8fcbc09f23441e5fd2f8dffed523952dd",
        "counters": {
            "domain_architectures": 75992,
            "entries": 10,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "smart": 1,
                "profile": 1,
                "ssf": 1,
                "cdd": 1,
                "panther": 1,
                "pfam": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 75992
        }
    }
}