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{
    "metadata": {
        "accession": "A0A2I4CPU2",
        "id": "A0A2I4CPU2_AUSLI",
        "source_organism": {
            "taxId": "52670",
            "scientificName": "Austrofundulus limnaeus",
            "fullName": "Austrofundulus limnaeus (Annual killifish)"
        },
        "name": "Flap endonuclease 1",
        "description": [
            "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA"
        ],
        "length": 380,
        "sequence": "MGIHGLAKLIADHAPGAIKEQDIKNYFGRKIAIDASMCIYQFLIAVRQDGNVLQNEDGETTSHLMGMFYRTIRMLENGIKPVYVFDGKPPQLKSAELEKRGERRAESEKLLAQAQELGEQENIDKFSKRLVKVTKQHNDECKKLLSLMGVPYIEAPCEAEASCAALVKAGKVFATATEDMDGLTFGTNVLLRHLTASEAKKLPIQEFHFNRILQDMGLTNEQFIDLCILLGCDYCGTIKGIGPKRAIDLIRQHGCIEDILDNIDSNKHPAPEDWLYKEARNLFIKPEVVDCSSVDLKWTEPDEDSLIQFMCNEKQFSEDRIRNGCKKMVKSRQGSTQGRLDSFFTVTGSLSSKRKQPEIKGSAKKKQKTGATPGKFRKGK",
        "proteome": "UP000192220",
        "gene": "fen1",
        "go_terms": [
            {
                "identifier": "GO:0004518",
                "name": "nuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003824",
                "name": "catalytic activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016788",
                "name": "hydrolase activity, acting on ester bonds",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "65d1dc0c0ec0da2fac076aba8890f2d85fde3ea5",
        "counters": {
            "domain_architectures": 15963,
            "entries": 24,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 3,
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 2,
                "pfam": 2,
                "panther": 1,
                "hamap": 1,
                "prosite": 2,
                "prints": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 15963
        }
    }
}