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{
    "metadata": {
        "accession": "A0A1L8FPD2",
        "id": "A0A1L8FPD2_XENLA",
        "source_organism": {
            "taxId": "8355",
            "scientificName": "Xenopus laevis",
            "fullName": "Xenopus laevis (African clawed frog)"
        },
        "name": "5-hydroxytryptamine receptor 6",
        "description": [
            "G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling"
        ],
        "length": 422,
        "sequence": "MDEHWDGPYGKGMTQRSSPHGPNIWVAAFLCLIILLTTLGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNELYGKWILDVDFCCIWYSFDVMCCSASILNLCVISLDRYLLIISPLKYKLRMTSCRALCLILATWTLAALASFLPIEMGWHEQDFDLQHINMTSGAEEKQCRLIVSLPYALVASCLTFFLPSVAISFTYCRILLAARKQAVQVASLVTNVPSATEDHAQVLVLPVVDSRKFVTKHSKKALKASLTLGILLGMFFVAWLPFFVANVVQAVCDCVPPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAMGKYLPCCRRSRVISLSIRNSNSAPRLGLSLRNVLTLRGETESMYSATLGNEHLLPNSKDHSTDRLPVTAADSVNLFDLEQELQVHHLNTPMD",
        "proteome": "UP000186698",
        "gene": "htr6.L",
        "go_terms": [
            {
                "identifier": "GO:0004993",
                "name": "G protein-coupled serotonin receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007186",
                "name": "G protein-coupled receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0004930",
                "name": "G protein-coupled receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "587fa3dbe4504dc051049f3cca904dd9ab631b87",
        "counters": {
            "domain_architectures": 394800,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "cdd": 1,
                "smart": 1,
                "profile": 1,
                "pfam": 1,
                "panther": 1,
                "prints": 2,
                "prosite": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 394800
        }
    }
}