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{
    "metadata": {
        "accession": "A0A151N1D8",
        "id": "A0A151N1D8_ALLMI",
        "source_organism": {
            "taxId": "8496",
            "scientificName": "Alligator mississippiensis",
            "fullName": "Alligator mississippiensis (American alligator)"
        },
        "name": "Diacylglycerol lipase-beta",
        "description": [
            "Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages"
        ],
        "length": 674,
        "sequence": "MPGLVLFGRRWAIGSDDFVFPGAFELFLRLIWWVGVLVLYSVHKERFNCTGGGLLHTYLLVLLVLLAAIICAVSAIVCVSMRGTISNPGPRKSLPKLLYTRLFLFLPEFVWATVGAIWVSDSRVHCEKTVVNAIFGTVIASWIIIIFTIIAIVIVFDPLGGKKTLYLTDAIDRNLESSQSGQLFYNVKKTATRVWEKRIRLLCCCIVQNDDHRVAFTSIAELFSSYFSDTDLVPSDIAAGLSLLHQEQDLVENCPKDPEEILCHSPTSPVADDLDVELENAAHYMQFAAAAYGWPYYIFTNPFTALCRLNRDCCRNRATDPDIIGGDCLNFHFGSILRITGLQYRDFIHISFHNKIFEIPFFVALDHKKEAVVVAVRGTLSFEDIITDLSADCEDLTLEDLLENGLVHKGITQAANYIYRKLINDGILNQALTIAPEYKVVIVGHSLGAGTASILAVLLKNSFPMLRCYAFSPPGGLLSKSLADYTKHFIISVIVGKDLVARLSMPNMEDLKRRIVRIVANCNRPKYQILLRGCWYEVFGGNPDNFPTELDGRSQDTLTQPLLAEESLMVHHSPSYSTLGDESHLNSPQYPQLYLPGKIIHIVEESSTRRWCSSDIKYTARWSKETVFRNILISPKMITDHMPDVVLKALNSLSQDKASCISCQTQDDFNTNVV",
        "proteome": "UP000050525",
        "gene": "DAGLB",
        "go_terms": [
            {
                "identifier": "GO:0006629",
                "name": "lipid metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "fc928dcef83934fc9f01d159aae73bf9e479b9f4",
        "counters": {
            "domain_architectures": 46337,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "cdd": 1,
                "ssf": 1,
                "pfam": 1,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 46337
        }
    }
}