General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A077RAN8",
        "id": "A0A077RAN8_9BASI",
        "source_organism": {
            "taxId": "1398559",
            "scientificName": "Melanopsichium pennsylvanicum 4",
            "fullName": "Melanopsichium pennsylvanicum 4"
        },
        "name": "PAN2-PAN3 deadenylation complex subunit PAN3",
        "description": [
            "Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1"
        ],
        "length": 812,
        "sequence": "MQQHQHSQQQQIPPAFNGALPSKPTRSSAIPIIAPASTPPPSAKPVISYGTVAGSGGIATPEHVKSPVASNVTTPSRKSCRNVAIYGHCKYQNDGCPFDHSSVSTGATSTVAAQTQKSPAAQFSSGLSAVSRPSPANSPNKTRGGINIPSSPLKGALSARNVAAAVFVPKTNGGSSPSLSAATAAPAPRSALEGLTTEVDEMRIESGNTKNFTPNAHSHNGPGTPTLYNSNYDGDAVNSSYDPPYPVPSGAMPHDTHIGTSTPSSTNAPLQSQPSRPYNPYEHMNEFGDPAPQGPPGLGLGGGMDYYTAANGAAKLRQPLQYHLYAPPLPHVSNLHPHHLTANAFFLNPNQREELQRRQEAMLASVPPPELGGPNLPEELHVYHSLVPLEHPGSGASATMGMPPGLIDPRMGAPGANGATGASGDHSKVFGYRSHSYKATCTLDGKRYVLRRLEGFRLQHEAAIGLVERWRRVRHPSIVSVREAFTTRAFGDQSIVFVYDYHPLATTLYAEHMTIKAAQPDRRTGRLQPVSMQVPERTLWSYLCQLTSALRTVHSSNLAARCIEASKVLRTGKNRVRINCCSVFDVIAYSPDESGAEPLKAQQLEDLVNLGALLVSIGLNSISATNDIASSLAIFAGRYSAELKNIVAWLVGQSPAPSESTEDAAEVPRTVGELVKVLGIHCADEMDSALNYTDLMENSLMKELENGRLVRLLCKFGFINERPEFDHDPRWAETGDRYVIKLFRDHVFHSVDEAGRPVVDLSHILTNLNKLDAGTDEKIMLTSRDEHSCLVVSYREIKNCIESAFQDLSRTR",
        "proteome": null,
        "gene": "PAN3",
        "go_terms": [
            {
                "identifier": "GO:0046872",
                "name": "metal ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003723",
                "name": "RNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0000289",
                "name": "nuclear-transcribed mRNA poly(A) tail shortening",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0031251",
                "name": "PAN complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "fdc39564c5ff59f732227a24eded50b84a79a2ae",
        "counters": {
            "domain_architectures": 998,
            "entries": 14,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 4,
                "profile": 1,
                "pfam": 2,
                "ssf": 1,
                "hamap": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 998
        }
    }
}