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{
"metadata": {
"accession": "SM01299",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "smart",
"member_databases": null,
"integrated": "IPR029244",
"hierarchy": null,
"name": {
"name": "N-term cysteine-rich ER, FAM69",
"short": "PIP49_N"
},
"description": [
{
"text": "<p>The FAM69 family of cysteine-rich type II transmembrane proteins localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases [cite:PUB00066680]. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished).</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00066680": {
"PMID": 21334309,
"ISBN": null,
"volume": "406",
"issue": "3",
"year": 2011,
"title": "Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins.",
"URL": null,
"raw_pages": "471-7",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Tennant-Eyles AJ",
"Moffitt H",
"Whitehouse CA",
"Roberts RG."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbrc.2011.02.076"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3308,
"pathways": 0,
"proteins": 3308,
"proteomes": 922,
"sets": 0,
"structural_models": {
"alphafold": 3033,
"bfvd": 0
},
"structures": 0,
"taxa": 3040
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
