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{
    "metadata": {
        "accession": "SM00223",
        "entry_id": null,
        "type": "domain",
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        "source_database": "smart",
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        "integrated": "IPR000177",
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        "name": {
            "name": "APPLE domain",
            "short": "APPLE"
        },
        "description": [
            {
                "text": "<p>Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.</p>",
                "llm": false,
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            "matches": 12866,
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            "proteins": 5740,
            "proteomes": 1355,
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            "structural_models": {
                "alphafold": 4301,
                "bfvd": 6
            },
            "structures": 18,
            "taxa": 3726
        },
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        "cross_references": {},
        "is_llm": false,
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        "representative_structure": {
            "accession": "6i44",
            "name": "Allosteric activation of human prekallikrein by apple domain disc rotation"
        }
    }
}