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{
"metadata": {
"accession": "PS00897",
"entry_id": null,
"type": "conserved_site",
"go_terms": null,
"source_database": "prosite",
"member_databases": null,
"integrated": "IPR018457",
"hierarchy": null,
"name": {
"name": "LacY family proton/sugar symporters signature 2",
"short": "LACY_2"
},
"description": [
{
"text": "<p>In bacteria there are a number of families of transport proteins that mediate\nthe intake of a variety of sugars with the concomitant uptake of hydrogen\nions (proton symporters) [[cite:PUB00005398]]. One of these families is composed [[cite:PUB00003754]] of the\nfollowing proteins:\n\n - Escherichia coli and Klebsiella pneumoniae lactose permease (gene lacY)\n which are responsible for the transport of beta-galactosides into the cell.\n - Escherichia coli plasmid pRsd2 raffinose permease (gene rafB).\n - Escherichia coli sucrose permease (gene cscB).\n\nThese integral membrane proteins are predicted to comprise twelve membrane\nspanning domains. As signature patterns we selected two conserved regions\nthat both correspond to cytoplasmic loops: between the second and third\ntransmembrane regions for the first pattern and between the eight and ninth\nfor the second pattern.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00005398": {
"PMID": 8438231,
"ISBN": null,
"volume": "18",
"issue": "1",
"year": 1993,
"title": "A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.",
"URL": null,
"raw_pages": "13-20",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Marger MD",
"Saier MH Jr."
],
"DOI_URL": "http://dx.doi.org/10.1016/0968-0004(93)90081-W"
},
"PUB00003754": {
"PMID": 1435727,
"ISBN": null,
"volume": "235",
"issue": "1",
"year": 1992,
"title": "Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132.",
"URL": null,
"raw_pages": "22-32",
"medline_journal": "Mol Gen Genet",
"ISO_journal": "Mol. Gen. Genet.",
"authors": [
"Bockmann J",
"Heuel H",
"Lengeler JW."
],
"DOI_URL": "http://dx.doi.org/10.1007/BF00286177"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 898,
"pathways": 0,
"proteins": 898,
"proteomes": 247,
"sets": 0,
"structural_models": {
"alphafold": 766,
"bfvd": 0
},
"structures": 11,
"taxa": 537
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
