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{
"metadata": {
"accession": "PS50896",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "profile",
"member_databases": null,
"integrated": "IPR006594",
"hierarchy": null,
"name": {
"name": "LIS1 homology (LisH) motif profile",
"short": "LISH"
},
"description": [
{
"text": "<p>The 33-residue LIS1 homology (LisH) motif is found in eukaryotic intracellular\nproteins involved in microtubule dynamics, cell migration, nucleokinesis and\nchromosome segregation. The LisH motif is likely to possess a conserved\nprotein-binding function and it has been proposed that LisH motifs contribute\nto the regulation of microtubule dynamics, either by mediating dimerization,\nor else by binding cytoplasmic dynein heavy chain or microtubules directly.\nThe LisH motif is found associated to other domains, such as WD-40, SPRY, Kelch, AAA ATPase, RasGEF, or HEAT\n[[cite:PUB00007968]][[cite:PUB00011841]][[cite:PUB00011842]].\n\nThe secondary structure of the LisH domain is predicted to be two alpha-\nhelices [[cite:PUB00007968]].\n\nSome proteins known to contain a LisH motif are listed below:\n\n - Animal LIS1. It regulates cytoplasmic dynein function. In human, children\n with defects in LIS1 suffer from Miller-Dieker lissencephaly, a brain\n malformation that results in severe retardation, epilepsy and an early\n death.\n - Emericella nidulans nuclear migration protein nudF, the orthologue of LIS1.\n - Eukaryotic RanBPM, a Ran binding protein involved in microtubule\n nucleation.\n - Eukaryotic Nopp140, a nucleolar phosphoprotein.\n - Mammalian treacle, a nucleolar protein. In human, defects in treacle are\n the cause of Treacher Collins syndrome (TCS), an autosomal dominant\n disorder of craniofacial development.\n - Animal muskelin. It acts as a mediator of cell spreading and cytoskeletal\n responses to the extracellular matrix component thrombospondin 1.\n - Animal transducin beta-like 1 protein (TBL1).\n - Plant tonneau.\n - Arabidopsis thaliana LEUNIG, a putative transcriptional corepressor that\n regulates AGAMOUS expression during flower development.\n - Fungal aimless RasGEF.\n - Leishmania major katanin-like protein.\n\nThe C-terminal to LisH (CTLH) motif is a predicted alpha-helical sequence of\nunknown function that is found adjacent to the LisH motif in a number of these\nproteins but is absent in other (e.g. LIS1) [[cite:PUB00007968]][[cite:PUB00011841]][[cite:PUB00011842]]. The CTLH domain can also\nbe found in the absence of the LisH motif, like in:\n\n - Arabidopsis thaliana hypothetical protein MUD21.5.\n - Yeast protein RMD5.\n\nThe profiles we developed cover respectively the entire LisH and CTLH motifs.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00011841": {
"PMID": 12384287,
"ISBN": null,
"volume": "297",
"issue": "1-2",
"year": 2002,
"title": "Characterization of a Drosophila melanogaster orthologue of muskelin.",
"URL": null,
"raw_pages": "69-78",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Adams JC."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0378-1119(02)00887-9"
},
"PUB00007968": {
"PMID": 11734546,
"ISBN": null,
"volume": "10",
"issue": "24",
"year": 2001,
"title": "A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration.",
"URL": null,
"raw_pages": "2813-20",
"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum. Mol. Genet.",
"authors": [
"Emes RD",
"Ponting CP."
],
"DOI_URL": "http://dx.doi.org/10.1093/hmg/10.24.2813"
},
"PUB00011842": {
"PMID": 12559565,
"ISBN": null,
"volume": "303",
"issue": null,
"year": 2003,
"title": "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.",
"URL": null,
"raw_pages": "47-54",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Umeda M",
"Nishitani H",
"Nishimoto T."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0378-1119(02)01153-8"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 79824,
"pathways": 0,
"proteins": 78918,
"proteomes": 3984,
"sets": 0,
"structural_models": {
"alphafold": 66170,
"bfvd": 1
},
"structures": 98,
"taxa": 11201
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
