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"name": {
"name": "GATA-type zinc finger domain profile",
"short": "GATA_ZN_FINGER_2"
},
"description": [
{
"text": "<p>The GATA family of transcription factors are proteins that bind to DNA sites\nwith the consensus sequence (A/T)GATA(A/G), found within the regulatory region\nof a number of genes. Proteins currently known to belong to this family are:\n\n - GATA-1 [[cite:PUB00004057]] (also known as Eryf1, GF-1 or NF-E1), which binds to the GATA\n region of globin genes and other genes expressed in erythroid cells. It is\n a transcriptional activator which probably serves as a general 'switch'\n factor for erythroid development.\n - GATA-2 [[cite:PUB00002653]], a transcriptional activator which regulates endothelin-1 gene\n expression in endothelial cells.\n - GATA-3 [[cite:PUB00001204]], a transcriptional activator which binds to the enhancer of the\n T-cell receptor alpha and delta genes.\n - GATA-4 [[cite:PUB00003674]], a transcriptional activator expressed in endodermally derived\n tissues and heart.\n - Drosophila protein pannier (or DGATAa) (gene pnr) which acts as a repressor\n of the achaete-scute complex (as-c).\n - Bombyx mori BCFI [[cite:PUB00002835]], which regulates the expression of chorion genes.\n - Caenorhabditis elegans elt-1 and elt-2, transcriptional activators of genes\n containing the GATA region, including vitellogenin genes [[cite:PUB00002909]].\n - Ustilago maydis urbs1 [[cite:PUB00003693]], a protein involved in the repression of the\n biosynthesis of siderophores.\n - Fission yeast protein GAF2.\n\nAll these transcription factors contain a pair of highly similar 'zinc finger'\ntype domains with the consensus sequence C-x2-C-x17-C-x2-C.\n\nSome other proteins contain a single zinc finger motif highly related to those\nof the GATA transcription factors. These proteins are:\n\n - Drosophila box A-binding factor (ABF) (also known as protein serpent (gene\n srp)) which may function as a transcriptional activator protein and may\n play a key role in the organogenesis of the fat body.\n - Emericella nidulans areA [[cite:PUB00005516]], a transcriptional activator which mediates\n nitrogen metabolite repression.\n - Neurospora crassa nit-2 [[cite:PUB00003659]], a transcriptional activator which turns on the\n expression of genes coding for enzymes required for the use of a variety of\n secondary nitrogen sources, during conditions of nitrogen limitation.\n - Neurospora crassa white collar proteins 1 and 2 (WC-1 and WC-2), which\n control expression of light-regulated genes.\n - Saccharomyces cerevisiae DAL81 (or UGA43), a negative nitrogen regulatory\n protein.\n - Saccharomyces cerevisiae GLN3, a positive nitrogen regulatory protein.\n - Saccharomyces cerevisiae GAT1 to GAT4.\n - Saccharomyces cerevisiae GZF3.</p>",
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"literature": {
"PUB00003674": {
"PMID": 1875944,
"ISBN": null,
"volume": "11",
"issue": "9",
"year": 1991,
"title": "elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family.",
"URL": null,
"raw_pages": "4651-9",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Spieth J",
"Shim YH",
"Lea K",
"Conrad R",
"Blumenthal T."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=1875944"
},
"PUB00003659": {
"PMID": 2137552,
"ISBN": null,
"volume": "10",
"issue": "3",
"year": 1990,
"title": "nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain.",
"URL": null,
"raw_pages": "1056-65",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Fu YH",
"Marzluf GA."
],
"DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=2137552&action=stream&blobtype=pdf"
},
"PUB00004057": {
"PMID": 2104960,
"ISBN": null,
"volume": "343",
"issue": "6253",
"year": 1990,
"title": "Structure and evolution of a human erythroid transcription factor.",
"URL": null,
"raw_pages": "92-6",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Trainor CD",
"Evans T",
"Felsenfeld G",
"Boguski MS."
],
"DOI_URL": "http://dx.doi.org/10.1038/343092a0"
},
"PUB00003693": {
"PMID": 8413298,
"ISBN": null,
"volume": "13",
"issue": "11",
"year": 1993,
"title": "urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1.",
"URL": null,
"raw_pages": "7091-100",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Voisard C",
"Wang J",
"McEvoy JL",
"Xu P",
"Leong SA."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8413298"
},
"PUB00001204": {
"PMID": 1827068,
"ISBN": null,
"volume": "10",
"issue": "5",
"year": 1991,
"title": "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.",
"URL": null,
"raw_pages": "1187-92",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Ho IC",
"Vorhees P",
"Marin N",
"Oakley BK",
"Tsai SF",
"Orkin SH",
"Leiden JM."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1827068"
},
"PUB00002653": {
"PMID": 1714909,
"ISBN": null,
"volume": "266",
"issue": "24",
"year": 1991,
"title": "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells.",
"URL": null,
"raw_pages": "16188-92",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Lee ME",
"Temizer DH",
"Clifford JA",
"Quertermous T."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/266/24/16188.pdf"
},
"PUB00005516": {
"PMID": 2511649,
"ISBN": null,
"volume": "5",
"issue": "9",
"year": 1989,
"title": "Aspergillus and mouse share a new class of 'zinc finger' protein.",
"URL": null,
"raw_pages": "291",
"medline_journal": "Trends Genet",
"ISO_journal": "Trends Genet.",
"authors": [
"Arst HN Jr",
"Kudla B",
"Martinez-Rossi N",
"Caddick MX",
"Sibley S",
"Davies RW."
],
"DOI_URL": "http://dx.doi.org/10.1016/0168-9525(89)90105-4"
},
"PUB00002835": {
"PMID": 8144656,
"ISBN": null,
"volume": "269",
"issue": "14",
"year": 1994,
"title": "GATA-type zinc finger motif-containing sequences and chorion gene transcription factors of the silkworm Bombyx mori.",
"URL": null,
"raw_pages": "10660-7",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Drevet JR",
"Skeiky YA",
"Iatrou K."
],
"DOI_URL": "http://intl.jbc.org/cgi/content/abstract/269/14/10660"
},
"PUB00002909": {
"PMID": 7782329,
"ISBN": null,
"volume": "270",
"issue": "24",
"year": 1995,
"title": "elt-2, a second GATA factor from the nematode Caenorhabditis elegans.",
"URL": null,
"raw_pages": "14666-71",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Hawkins MG",
"McGhee JD."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.270.24.14666"
}
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"accession": "4hc9",
"name": "DNA binding by GATA transcription factor-complex 3"
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