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{
    "metadata": {
        "accession": "PR01908",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "prints",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "Atypical dual specificity phosphatase family",
            "short": "ADSPHPHTASE"
        },
        "description": [
            {
                "text": "<p>  Dual Specificity Phosphatases (DUSPs) are members of the superfamily of Protein Tyrosine Phosphatases (PTPs). They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. Many of these proteins have been related to the MAP kinase signalling pathway and hence they are also termed MAP kinase phosphatases (MKPs). A group of DUSPs share a high degree of similarity with the MKP subgroup, but lack the N-terminal regulatory domain, which provides the substrate specificity towards the MAP kinases. These proteins form a heterogeneous group and have in common the presence of a single catalytic PTP domain. They are small-sized and have been named Low Molecular Weight-DUSPs (LMW-DUSPs) or Atypical-DUSPs. VHR was the first characterised member of this subfamily; its crystal structure is known [1281549,8650541]. </p> <p> The functions of many of the members of this group remain unknown, although some have been related to regulation of MAP kinase pathways [10224087,11971192,15796912]. VHR has also been related to the control of cell-senescence [16604064]. On the basis of sequence similarity, this family can be subdivided into two groups, for convenience termed A and B. </p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 56686,
            "pathways": 0,
            "proteins": 14671,
            "proteomes": 1588,
            "sets": 0,
            "structural_models": {
                "alphafold": 13514,
                "bfvd": 2
            },
            "structures": 62,
            "taxa": 5503
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}