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"metadata": {
"accession": "PR01890",
"entry_id": null,
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"name": {
"name": "Neuropeptide W precursor",
"short": "PPNRPEPTIDEW"
},
"description": [
{
"text": "<p> Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified and named preproneuropeptide B and preproneuropeptide W [<cite id=\"PUB00013914\"/>,<cite id=\"PUB00013915\"/>,<cite id=\"PUB00013916\"/>]. In humans, each precursor contains a signal sequence and two dibasic cleavage sites. Alternative cleavage of these sites results in long (29 or 30 amino acid) and short (23 amino acid) forms of the resultant neuropeptides [<cite id=\"PUB00013914\"/>,<cite id=\"PUB00013915\"/>]. Murine, rat and bovine versions of preproneuropeptide B, however, contain only the second cleavage site, resulting in only the long form of neuropeptide B [<cite id=\"PUB00013915\"/>,<cite id=\"PUB00013916\"/>]. Neuropeptide W has a more limited distribution in the brain than neuropeptide B and is found at highest levels in the substantia nigra, suggesting an involvement in locomotor control [<cite id=\"PUB00013915\"/>]. In the periphery, neuropeptide W is more widespread than neuropeptide B. Like neuropeptide B, it is expressed at high levels in testis, ovary, uterus, placenta, spleen, lymph nodes and peripheral blood leukocytes, indicating potential roles in the reproductive and immune systems [<cite id=\"PUB00013915\"/>]. In addition, however, neuropeptide W has been found at high levels in the liver, stomach and trachea [<cite id=\"PUB00013915\"/>]. Intracerebroventricular administration of neuropeptide W in rats has been reported to produce an acute increase in food intake and to stimulate prolactin release [<cite id=\"PUB00013914\"/>]. </p>",
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"literature": {
"PUB00013915": {
"PMID": 12401809,
"ISBN": null,
"volume": "278",
"issue": "2",
"year": 2003,
"title": "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.",
"URL": null,
"raw_pages": "776-83",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Brezillon S",
"Lannoy V",
"Franssen JD",
"Le Poul E",
"Dupriez V",
"Lucchetti J",
"Detheux M",
"Parmentier M."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M206396200"
},
"PUB00013914": {
"PMID": 12130646,
"ISBN": null,
"volume": "277",
"issue": "39",
"year": 2002,
"title": "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.",
"URL": null,
"raw_pages": "35826-32",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Shimomura Y",
"Harada M",
"Goto M",
"Sugo T",
"Matsumoto Y",
"Abe M",
"Watanabe T",
"Asami T",
"Kitada C",
"Mori M",
"Onda H",
"Fujino M."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M205337200"
},
"PUB00013916": {
"PMID": 12118011,
"ISBN": null,
"volume": "277",
"issue": "37",
"year": 2002,
"title": "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.",
"URL": null,
"raw_pages": "34010-6",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Fujii R",
"Yoshida H",
"Fukusumi S",
"Habata Y",
"Hosoya M",
"Kawamata Y",
"Yano T",
"Hinuma S",
"Kitada C",
"Asami T",
"Mori M",
"Fujisawa Y",
"Fujino M."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M205883200"
}
},
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},
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"taxa": 346
},
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"is_llm": false,
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}
}
