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{
"metadata": {
"accession": "PF23248",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR057043",
"hierarchy": null,
"name": {
"name": "PARP14, second type I KH domain",
"short": "KH_PARP14_2"
},
"description": [
{
"text": "<p>This domain is found in human Protein mono-ADP-ribosyltransferase PARP14 and related proteins. PARP14 is a large multidomain protein which in the N-terminal half contains a series of consecutive RRM and KH domains that are known to be nucleic acid-binding. PARP14 is involved in multiple signaling pathways linked to cancer, inflammation, and infection. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins [[cite:PUB00083477],[cite:PUB00155694],[cite:PUB00146699]]. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation [[cite:PUB00146699]]. The domain represented by this entry is a KH domain found second in the human PARP14.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00083477": {
"PMID": 16061477,
"ISBN": null,
"volume": "280",
"issue": "40",
"year": 2005,
"title": "B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.",
"URL": null,
"raw_pages": "33756-65",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Aguiar RC",
"Takeyama K",
"He C",
"Kreinbrink K",
"Shipp MA."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M505408200"
},
"PUB00155694": {
"PMID": 18851833,
"ISBN": null,
"volume": "32",
"issue": "1",
"year": 2008,
"title": "Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.",
"URL": null,
"raw_pages": "57-69",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol Cell",
"authors": [
"Kleine H",
"Poreba E",
"Lesniewicz K",
"Hassa PO",
"Hottiger MO",
"Litchfield DW",
"Shilton BH",
"Luscher B."
],
"DOI_URL": "https://doi.org/10.1016/j.molcel.2008.08.009"
},
"PUB00146699": {
"PMID": 25043379,
"ISBN": null,
"volume": "5",
"issue": null,
"year": 2014,
"title": "Family-wide analysis of poly(ADP-ribose) polymerase activity.",
"URL": null,
"raw_pages": "4426",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Vyas S",
"Matic I",
"Uchima L",
"Rood J",
"Zaja R",
"Hay RT",
"Ahel I",
"Chang P."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "CL0007",
"name": "KH"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 241,
"interactions": 0,
"matches": 1750,
"pathways": 0,
"proteins": 1712,
"proteomes": 650,
"sets": 1,
"structural_models": {
"alphafold": 108,
"bfvd": 0
},
"structures": 0,
"taxa": 2062
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 188,
"alignment:full": 1293
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
