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{
    "metadata": {
        "accession": "PF22513",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR053853",
        "hierarchy": null,
        "name": {
            "name": "Antitoxin FitA-like, ribbon-helix-helix",
            "short": "FitA-like_RHH"
        },
        "description": [
            {
                "text": "<p>This domain is found in Antitoxin FitA from Neisseria gonorrhoeae and similar bacterial sequences. FitA is the antitoxin component of a type II toxin-antitoxin (TA) system. It binds DNA through its ribbon-helix-helix motif (this entry) [[cite:PUB00039746]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00039746": {
                "PMID": 16982615,
                "ISBN": null,
                "volume": "281",
                "issue": "49",
                "year": 2006,
                "title": "Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.",
                "URL": null,
                "raw_pages": "37942-51",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Mattison K",
                    "Wilbur JS",
                    "So M",
                    "Brennan RG."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M605198200"
            }
        },
        "set_info": {
            "accession": "CL0057",
            "name": "Met_repress"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 16,
            "interactions": 0,
            "matches": 5352,
            "pathways": 0,
            "proteins": 5350,
            "proteomes": 2800,
            "sets": 1,
            "structural_models": {
                "alphafold": 3973,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 5438
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 313,
            "alignment:full": 2149
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7e4j",
            "name": "X-ray crystal structure of VapB12 antitoxin from mycobacterium tuberculosis in space group P41."
        }
    }
}