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{
    "metadata": {
        "accession": "PF21953",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR053828",
        "hierarchy": null,
        "name": {
            "name": "NAD nucleotidase, C-terminal domain",
            "short": "NadN_nucleosid_C"
        },
        "description": [
            {
                "text": "<p>This is the C-terminal domain of a family of Zn2+-dependent 5'-nucleotidases. This domain has a four-layered structure with a five-stranded beta-sheet forming the core [[cite:PUB00067290]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00067290": {
                "PMID": 21933152,
                "ISBN": null,
                "volume": "441",
                "issue": "1",
                "year": 2012,
                "title": "The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.",
                "URL": null,
                "raw_pages": "131-41",
                "medline_journal": "Biochem J",
                "ISO_journal": "Biochem. J.",
                "authors": [
                    "Garavaglia S",
                    "Bruzzone S",
                    "Cassani C",
                    "Canella L",
                    "Allegrone G",
                    "Sturla L",
                    "Mannino E",
                    "Millo E",
                    "De Flora A",
                    "Rizzi M."
                ],
                "DOI_URL": "http://dx.doi.org/10.1042/BJ20111263"
            }
        },
        "set_info": {
            "accession": "CL0781",
            "name": "NadN_C"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 45,
            "interactions": 0,
            "matches": 2699,
            "pathways": 0,
            "proteins": 2583,
            "proteomes": 1344,
            "sets": 1,
            "structural_models": {
                "alphafold": 2273,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 3044
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 339,
            "alignment:full": 1821
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}