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{
    "metadata": {
        "accession": "PF21222",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR048524",
        "hierarchy": null,
        "name": {
            "name": "Lysosome-associated membrane glycoprotein 2, transmembrane segment",
            "short": "Lamp2_2nd"
        },
        "description": [
            {
                "text": "<p>This domain is found in Lysosome-associated membrane glycoprotein 2 from humans (Lamp2) and similar proteins from vertebrates. Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains, a single transmembrane domain (this entry) and a short C-terminal cytosolic tail. It adopts a trimeric configuration, and the transmembrane domains of the three monomers form a three-helix bundle structure [[cite:PUB00151730]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00151730": {
                "PMID": 25342746,
                "ISBN": null,
                "volume": "289",
                "issue": "51",
                "year": 2014,
                "title": "Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy.",
                "URL": null,
                "raw_pages": "35111-23",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Rout AK",
                    "Strub MP",
                    "Piszczek G",
                    "Tjandra N."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 37,
            "interactions": 0,
            "matches": 3025,
            "pathways": 0,
            "proteins": 3008,
            "proteomes": 1121,
            "sets": 0,
            "structural_models": {
                "alphafold": 2770,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 3883
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 2,
            "alignment:full": 2077
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}