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{
    "metadata": {
        "accession": "PF20644",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR048540",
        "hierarchy": null,
        "name": {
            "name": "Rrn7/TAF1B, N-terminal cyclin domain",
            "short": "Rrn7_cyclin_N"
        },
        "description": [
            {
                "text": "<p>Rrn7 from yeast and its orthologue TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B) from human, are TFIIB-like factors components of RNA polymerase I core factor complex. They contain two cyclin fold domains which interact with both Rrn6 and Rrn11 and form the fingers of the core factor which resembles a right hand. N-terminal regions of both Rrn11 and Rrn6 compose the palm, the thumb is composed by the C-terminal of Rrn11 and the knuckles consist of the C-terminal half of Rrn6. This is the first cyclin domain (cyclin I) from yeast Rrn7 and its orthologues from animals and plants TAF1B [[cite:PUB00099775],[cite:PUB00100002]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00100002": {
                "PMID": 28623663,
                "ISBN": null,
                "volume": "6",
                "issue": null,
                "year": 2017,
                "title": "Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "Elife",
                "ISO_journal": "Elife",
                "authors": [
                    "Han Y",
                    "Yan C",
                    "Nguyen THD",
                    "Jackobel AJ",
                    "Ivanov I",
                    "Knutson BA",
                    "He Y."
                ],
                "DOI_URL": null
            },
            "PUB00099775": {
                "PMID": 28340337,
                "ISBN": null,
                "volume": "169",
                "issue": "1",
                "year": 2017,
                "title": "Structural Basis of RNA Polymerase I Transcription Initiation.",
                "URL": null,
                "raw_pages": "120-131.e22",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Engel C",
                    "Gubbey T",
                    "Neyer S",
                    "Sainsbury S",
                    "Oberthuer C",
                    "Baejen C",
                    "Bernecky C",
                    "Cramer P."
                ],
                "DOI_URL": null
            }
        },
        "set_info": {
            "accession": "CL0065",
            "name": "Cyclin"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 77,
            "interactions": 0,
            "matches": 3296,
            "pathways": 0,
            "proteins": 3216,
            "proteomes": 2345,
            "sets": 1,
            "structural_models": {
                "alphafold": 2857,
                "bfvd": 0
            },
            "structures": 17,
            "taxa": 6401
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 18,
            "alignment:full": 2249
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}