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{
"metadata": {
"accession": "PF19462",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR046041",
"hierarchy": null,
"name": {
"name": "Family of unknown function (DUF5999)",
"short": "DUF5999"
},
"description": [
{
"text": "<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a protein from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus [[cite:PUB00098882]]. This family appears to be predominantly found in Actinobacteria.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "Domain_of_unknown_function",
"extract": "<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>",
"thumbnail": null
}
],
"literature": {
"PUB00098882": {
"PMID": 16766657,
"ISBN": null,
"volume": "103",
"issue": "25",
"year": 2006,
"title": "Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus.",
"URL": null,
"raw_pages": "9661-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Yanai K",
"Murakami T",
"Bibb M."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 7,
"interactions": 0,
"matches": 2384,
"pathways": 0,
"proteins": 2384,
"proteomes": 1345,
"sets": 0,
"structural_models": {
"alphafold": 1312,
"bfvd": 0
},
"structures": 0,
"taxa": 1607
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 91,
"alignment:full": 1067
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
