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{
    "metadata": {
        "accession": "PF18553",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR040725",
        "hierarchy": null,
        "name": {
            "name": "PheRS DNA binding domain 3",
            "short": "PheRS_DBD3"
        },
        "description": [
            {
                "text": "<p>This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. This domain belongs to a superfamily of 'winged helix' DNA-biding domains. The topology of DBD-1 and DBD-3 closely resembles the topology of the Z-DNA-binding domain Zalpha of double-stranded RNA (dsRNA) adenosine deaminase and other domains from DNA-binding proteins. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNAPhe binding and recognition, i.e., from the drastic reduction of aminoacylation activity seen upon removal of the N-terminal domains [[cite:PUB00091172]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00091172": {
                "PMID": 20223217,
                "ISBN": null,
                "volume": "18",
                "issue": "3",
                "year": 2010,
                "title": "Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns.",
                "URL": null,
                "raw_pages": "343-53",
                "medline_journal": "Structure",
                "ISO_journal": "Structure",
                "authors": [
                    "Finarov I",
                    "Moor N",
                    "Kessler N",
                    "Klipcan L",
                    "Safro MG."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.str.2010.01.002"
            }
        },
        "set_info": {
            "accession": "CL0123",
            "name": "HTH"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 98,
            "interactions": 0,
            "matches": 4271,
            "pathways": 0,
            "proteins": 4267,
            "proteomes": 2797,
            "sets": 1,
            "structural_models": {
                "alphafold": 3810,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 8006
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 75,
            "alignment:full": 2778
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}