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{
"metadata": {
"accession": "PF18523",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR041393",
"hierarchy": null,
"name": {
"name": "Sld3 N-terminal domain",
"short": "Sld3_N"
},
"description": [
{
"text": "<p>Sld3 is conserved in yeast and fungi, and treslin, also known as Ticrr, has been identified as the functional counterpart of Sld3 in metazoans. However, they differ in size and amino acid sequence. Yeast Sld3 and its metazoan counterpart treslin are the hub proteins mediating protein associations critical for formation of the helicase. This entry represents the N-terminal domain of Sld3 which is shown to bind to the N-terminal domain of Sld7 [[cite:PUB00091502],[cite:PUB00103954]]. This domain adopts a Ku70-like beta-barrel fold which in Sld3 is truncated, containing five beta-strands [[cite:PUB00103954]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00091502": {
"PMID": 26249346,
"ISBN": null,
"volume": "71",
"issue": "Pt 8",
"year": 2015,
"title": "The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3.",
"URL": null,
"raw_pages": "1649-56",
"medline_journal": "Acta Crystallogr D Biol Crystallogr",
"ISO_journal": "Acta Crystallogr. D Biol. Crystallogr.",
"authors": [
"Itou H",
"Shirakihara Y",
"Araki H."
],
"DOI_URL": "https://doi.org/10.1107/S1399004715010457"
},
"PUB00103954": {
"PMID": 35091422,
"ISBN": null,
"volume": "5",
"issue": "5",
"year": 2022,
"title": "Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.",
"URL": null,
"raw_pages": "e202101088",
"medline_journal": "Life Sci Alliance",
"ISO_journal": "Life Sci Alliance",
"authors": [
"Ferreira P",
"Sanchez-Pulido L",
"Marko A",
"Ponting CP",
"Boos D."
],
"DOI_URL": null
},
"PUB00103962": {
"PMID": 22380713,
"ISBN": null,
"volume": "12",
"issue": "4",
"year": 2012,
"title": "Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast.",
"URL": null,
"raw_pages": "486-90",
"medline_journal": "FEMS Yeast Res",
"ISO_journal": "FEMS Yeast Res",
"authors": [
"Wang Z",
"Kim E",
"Leffak M",
"Xu YJ."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "CL0616",
"name": "SPOC"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 2,
"interactions": 0,
"matches": 57,
"pathways": 0,
"proteins": 57,
"proteomes": 44,
"sets": 1,
"structural_models": {
"alphafold": 51,
"bfvd": 0
},
"structures": 1,
"taxa": 97
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 17,
"alignment:full": 23
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
