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{
"metadata": {
"accession": "PF16282",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR032563",
"hierarchy": null,
"name": {
"name": "SANT/Myb-like domain of DAMP1",
"short": "SANT_DAMP1_like"
},
"description": [
{
"text": "<p>This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species [[cite:PUB00063468],[cite:PUB00076522]]. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site [[cite:PUB00005459]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00076522": {
"PMID": 21383065,
"ISBN": null,
"volume": "31",
"issue": "9",
"year": 2011,
"title": "Distinct roles of DMAP1 in mouse development.",
"URL": null,
"raw_pages": "1861-9",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Mohan KN",
"Ding F",
"Chaillet JR."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.01390-10"
},
"PUB00063468": {
"PMID": 19845771,
"ISBN": null,
"volume": "14",
"issue": "11",
"year": 2009,
"title": "Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.",
"URL": null,
"raw_pages": "1347-57",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Negishi M",
"Chiba T",
"Saraya A",
"Miyagi S",
"Iwama A."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2443.2009.01352.x"
},
"PUB00005459": {
"PMID": 8882580,
"ISBN": null,
"volume": "21",
"issue": "3",
"year": 1996,
"title": "The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.",
"URL": null,
"raw_pages": "87-8",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Aasland R",
"Stewart AF",
"Gibson T."
],
"DOI_URL": "http://dx.doi.org/10.1016/0968-0004(96)30009-1"
}
},
"set_info": {
"accession": "CL0123",
"name": "HTH"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 58,
"interactions": 0,
"matches": 4703,
"pathways": 0,
"proteins": 4697,
"proteomes": 3167,
"sets": 1,
"structural_models": {
"alphafold": 4228,
"bfvd": 0
},
"structures": 19,
"taxa": 8977
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 97,
"alignment:full": 3094
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4iej",
"name": "Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution"
}
}
}
