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{
    "metadata": {
        "accession": "PF15657",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR028048",
        "hierarchy": null,
        "name": {
            "name": "HNH/Endo VII superfamily nuclease toxins",
            "short": "Tox-HNH-EHHH"
        },
        "description": [
            {
                "text": "<p>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic conserved [ED]H motif and two histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system [[cite:PUB00066726]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00066726": {
                "PMID": 22731697,
                "ISBN": null,
                "volume": "7",
                "issue": null,
                "year": 2012,
                "title": "Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.",
                "URL": null,
                "raw_pages": "18",
                "medline_journal": "Biol Direct",
                "ISO_journal": "Biol. Direct",
                "authors": [
                    "Zhang D",
                    "de Souza RF",
                    "Anantharaman V",
                    "Iyer LM",
                    "Aravind L."
                ],
                "DOI_URL": "http://dx.doi.org/10.1186/1745-6150-7-18"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 162,
            "interactions": 0,
            "matches": 605,
            "pathways": 0,
            "proteins": 605,
            "proteomes": 275,
            "sets": 0,
            "structural_models": {
                "alphafold": 293,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 795
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 23,
            "alignment:full": 92
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}