HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "PF15365",
"entry_id": null,
"type": "conserved_site",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR028322",
"hierarchy": null,
"name": {
"name": "Proline-rich nuclear receptor coactivator motif",
"short": "PNRC"
},
"description": [
{
"text": "<p>This entry represents a conserved proline-rich region found in the Proline-rich nuclear receptor coactivator 1/2 (PNRC 1/2) and related eukaryotic proteins including Enhancer of mRNA-decapping protein 1/2 (Edc1/2). This region contains a conserved YAGxxF sequence motif at the beginning, known as 'activation motif', followed by Px[PA]xxxPxPxF motif, described as 'Dcp1 binding motif'. In Edc1, the latter interacts with the aromatic groove of Dcp1 EVH1 domain and thereby enhances the catalytic activity of the decapping enzyme. The recognition of this Edc1 motif by the Dcp1 EVH1 domain is reminiscent of the interactions that are observed between proline-rich sequences and, e.g., WW, SH3, and GYF domains [[cite:PUB00061792]]. In all cases, the central motif in the proline-rich sequence contacts a surface exposed cluster of aromatic residues in the protein domain. Mutation in the YAGxxF motif results in loss of the ability to activate the decapping complex [[cite:PUB00061792]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00110974": {
"PMID": 27354705,
"ISBN": null,
"volume": "22",
"issue": "9",
"year": 2016,
"title": "The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.",
"URL": null,
"raw_pages": "1360-72",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Wurm JP",
"Overbeck J",
"Sprangers R."
],
"DOI_URL": null
},
"PUB00061792": {
"PMID": 17971453,
"ISBN": null,
"volume": "283",
"issue": "1",
"year": 2008,
"title": "Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.",
"URL": null,
"raw_pages": "541-53",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Zhou D",
"Shen R",
"Ye JJ",
"Li Y",
"Tsark W",
"Isbell D",
"Tso P",
"Chen S."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M703234200"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 47,
"interactions": 0,
"matches": 5590,
"pathways": 0,
"proteins": 5588,
"proteomes": 2493,
"sets": 0,
"structural_models": {
"alphafold": 5065,
"bfvd": 0
},
"structures": 8,
"taxa": 6842
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 91,
"alignment:full": 3762
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5j3t",
"name": "Crystal structure of S. pombe Dcp2:Dcp1:Edc1 mRNA decapping complex"
}
}
}
