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{
"metadata": {
"accession": "PF14542",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR031165",
"hierarchy": null,
"name": {
"name": "GCN5-related N-acetyl-transferase",
"short": "Acetyltransf_CG"
},
"description": [
{
"text": "<p>This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterised by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "Acetyltransferase",
"extract": "<p>An <b>acetyltransferase</b> is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.</p>",
"thumbnail": null
}
],
"literature": {
"PUB00046616": {
"PMID": 18709443,
"ISBN": null,
"volume": "9",
"issue": "1-4",
"year": 2008,
"title": "Structure of an acetyl-CoA binding protein from Staphylococcus aureus representing a novel subfamily of GCN5-related N-acetyltransferase-like proteins.",
"URL": null,
"raw_pages": "7-20",
"medline_journal": "J Struct Funct Genomics",
"ISO_journal": "J. Struct. Funct. Genomics",
"authors": [
"Cort JR",
"Ramelot TA",
"Murray D",
"Acton TB",
"Ma LC",
"Xiao R",
"Montelione GT",
"Kennedy MA."
],
"DOI_URL": "http://dx.doi.org/10.1007/s10969-008-9041-z"
}
},
"set_info": {
"accession": "CL0257",
"name": "Acetyltrans"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 90,
"interactions": 0,
"matches": 20350,
"pathways": 0,
"proteins": 20343,
"proteomes": 11074,
"sets": 1,
"structural_models": {
"alphafold": 14744,
"bfvd": 0
},
"structures": 8,
"taxa": 18801
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 148,
"alignment:full": 8001
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5i0c",
"name": "Crystal structure of predicted acyltransferase YjdJ with acyl-CoA N-acyltransferase domain from Escherichia coli str. K-12"
}
}
}
