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{
    "metadata": {
        "accession": "PF11569",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR024578",
        "hierarchy": null,
        "name": {
            "name": "Homeodomain leucine-zipper encoding, Homez",
            "short": "Homez"
        },
        "description": [
            {
                "text": "<p>Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus [[cite:PUB00056069]]. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerisation and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain [[cite:PUB00056069]]. Homez is involved in a complex regulatory network [[cite:PUB00056069]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00056069": {
                "PMID": 12925734,
                "ISBN": null,
                "volume": "100",
                "issue": "18",
                "year": 2003,
                "title": "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.",
                "URL": null,
                "raw_pages": "10358-63",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Bayarsaihan D",
                    "Enkhmandakh B",
                    "Makeyev A",
                    "Greally JM",
                    "Leckman JF",
                    "Ruddle FH."
                ],
                "DOI_URL": "http://dx.doi.org/10.1073/pnas.1834010100"
            }
        },
        "set_info": {
            "accession": "CL0123",
            "name": "HTH"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 28,
            "interactions": 0,
            "matches": 1945,
            "pathways": 0,
            "proteins": 1945,
            "proteomes": 717,
            "sets": 1,
            "structural_models": {
                "alphafold": 1732,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 2223
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 2,
            "alignment:full": 1411
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}