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{
"metadata": {
"accession": "PF10937",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR020373",
"hierarchy": null,
"name": {
"name": "Alpha-ketoglutarate dehydrogenase component 4/YMR-31",
"short": "Kgd4-YMR31"
},
"description": [
{
"text": "<p>This entry represents the alpha-ketoglutarate dehydrogenase component 4 (Kgd4, also referred to as Ymr31/MRPS36) which was originally identified as a subunit of the mitochondrial ribosome [[cite:PUB00056057],[cite:PUB00012961],[cite:PUB00010175]]. Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase complex (OGDC). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, being found to contaminate ribosomal preparations [[cite:PUB00089008]]. Kgd4 plays an evolutionarily conserved role in the organisation of mitochondrial alpha-KGDH complexes of fungi and animals which constitutes a molecular adaptor that is necessary to form a stable alpha-KGDH enzyme complex [[cite:PUB00089008],[cite:PUB00100356]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00012961": {
"PMID": 9445368,
"ISBN": null,
"volume": "329 ( Pt 3)",
"issue": null,
"year": 1998,
"title": "Mitochondrial ribosomal proteins (MRPs) of yeast.",
"URL": null,
"raw_pages": "433-48",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Graack HR",
"Wittmann-Liebold B."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=9445368&action=stream&blobtype=pdf"
},
"PUB00056057": {
"PMID": 2693936,
"ISBN": null,
"volume": "219",
"issue": "1-2",
"year": 1989,
"title": "Cloning and analysis of the nuclear genes for two mitochondrial ribosomal proteins in yeast.",
"URL": null,
"raw_pages": "119-24",
"medline_journal": "Mol Gen Genet",
"ISO_journal": "Mol. Gen. Genet.",
"authors": [
"Matsushita Y",
"Kitakawa M",
"Isono K."
],
"DOI_URL": "http://dx.doi.org/10.1007/BF00261166"
},
"PUB00010175": {
"PMID": 12392552,
"ISBN": null,
"volume": "269",
"issue": "21",
"year": 2002,
"title": "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components.",
"URL": null,
"raw_pages": "5203-14",
"medline_journal": "Eur J Biochem",
"ISO_journal": "Eur. J. Biochem.",
"authors": [
"Gan X",
"Kitakawa M",
"Yoshino K",
"Oshiro N",
"Yonezawa K",
"Isono K."
],
"DOI_URL": "http://dx.doi.org/10.1046/j.1432-1033.2002.03226.x"
},
"PUB00100356": {
"PMID": 25165143,
"ISBN": null,
"volume": "25",
"issue": "21",
"year": 2014,
"title": "The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.",
"URL": null,
"raw_pages": "3342-9",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol Biol Cell",
"authors": [
"Heublein M",
"Burguillos MA",
"Vogtle FN",
"Teixeira PF",
"Imhof A",
"Meisinger C",
"Ott M."
],
"DOI_URL": null
},
"PUB00089008": {
"PMID": 25838379,
"ISBN": null,
"volume": "348",
"issue": "6230",
"year": 2015,
"title": "Ribosome. The structure of the human mitochondrial ribosome.",
"URL": null,
"raw_pages": "95-98",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Amunts A",
"Brown A",
"Toots J",
"Scheres SHW",
"Ramakrishnan V."
],
"DOI_URL": "https://doi.org/10.1126/science.aaa1193"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 24,
"interactions": 0,
"matches": 2206,
"pathways": 0,
"proteins": 2175,
"proteomes": 1697,
"sets": 0,
"structural_models": {
"alphafold": 1939,
"bfvd": 0
},
"structures": 0,
"taxa": 4669
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 53,
"alignment:full": 1512
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
