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{
"metadata": {
"accession": "PF10435",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR018954",
"hierarchy": null,
"name": {
"name": "Beta-galactosidase, domain 2",
"short": "BetaGal_dom2"
},
"description": [
{
"text": "<p>This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain is made up of 16 antiparallel beta-strands and an alpha-helix at its C terminus. The fold of this domain appears to be unique. In addition, the last seven strands of the domain form a subdomain with an immunoglobulin-like (I-type Ig) fold in which the first strand is divided between the two beta-sheets. In penicillin spp this strand is interrupted by a 12-residue insertion which forms an additional edge-strand to the second beta-sheet of the sub-domain. The remainder of the second domain forms a series of beta-hairpins at its N terminus, four strands of which are contiguous with part of the Ig-like sub-domain, forming in total a seven-stranded antiparallel beta-sheet. This domain is associated with family Glyco_hydro_35, [pfam:PF01301], which is N-terminal to it, but itself has no metazoan members.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00031444": {
"PMID": 15491613,
"ISBN": null,
"volume": "343",
"issue": "5",
"year": 2004,
"title": "Crystal structures of beta-galactosidase from Penicillium sp. and its complex with galactose.",
"URL": null,
"raw_pages": "1281-92",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Rojas AL",
"Nagem RA",
"Neustroev KN",
"Arand M",
"Adamska M",
"Eneyskaya EV",
"Kulminskaya AA",
"Garratt RC",
"Golubev AM",
"Polikarpov I."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2004.09.012"
}
},
"set_info": {
"accession": "CL0369",
"name": "GHD"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 114,
"interactions": 0,
"matches": 4386,
"pathways": 0,
"proteins": 4375,
"proteomes": 1577,
"sets": 1,
"structural_models": {
"alphafold": 3467,
"bfvd": 0
},
"structures": 15,
"taxa": 3177
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 116,
"alignment:full": 2779
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
