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{
"metadata": {
"accession": "PF07447",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR008986",
"hierarchy": null,
"name": {
"name": "Matrix protein VP40",
"short": "Matrix_Filo"
},
"description": [
{
"text": "<p>This family contains viral VP40 matrix proteins that seem to be restricted to the Filoviridae. These play an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. It has been shown that the N-terminal region of VP40 folds into a mixture of hexameric and octameric states - these may have distinct roles [[cite:PUB00013156]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "VP40",
"extract": "<p>In molecular biology, <b>VP40</b> is the name of a viral matrix protein. Most commonly, it is found in the <i>Ebola virus</i> (EBOV), a type of non-segmented, negative-strand RNA virus. Ebola virus causes a severe and often fatal haemorrhagic fever in humans, known as Ebola virus disease. The virus matrix protein VP40 is a major structural protein that plays a central role in virus assembly and budding at the plasma membrane of infected cells.</p>",
"thumbnail": null
}
],
"literature": {
"PUB00013156": {
"PMID": 12919741,
"ISBN": null,
"volume": "312",
"issue": "2",
"year": 2003,
"title": "Oligomerization and polymerization of the filovirus matrix protein VP40.",
"URL": null,
"raw_pages": "359-68",
"medline_journal": "Virology",
"ISO_journal": "Virology",
"authors": [
"Timmins J",
"Schoehn G",
"Kohlhaas C",
"Klenk HD",
"Ruigrok RW",
"Weissenhorn W."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0042-6822(03)00260-5"
}
},
"set_info": {
"accession": "CL0844",
"name": "Matrix_Mononaga"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 4,
"interactions": 0,
"matches": 347,
"pathways": 0,
"proteins": 332,
"proteomes": 11,
"sets": 1,
"structural_models": {
"alphafold": 0,
"bfvd": 10
},
"structures": 22,
"taxa": 48
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 2,
"alignment:full": 6
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1h2c",
"name": "Ebola virus matrix protein VP40 N-terminal domain in complex with RNA (High-resolution VP40[55-194] variant)."
}
}
}
