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{
    "metadata": {
        "accession": "PF07400",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR020438",
        "hierarchy": null,
        "name": {
            "name": "Interleukin 11",
            "short": "IL11"
        },
        "description": [
            {
                "text": "<p>This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11 [[cite:PUB00013131]]. Family members seem to be restricted to mammals.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": [
            {
                "title": "Interleukin_11",
                "extract": "<p><b>Interleukin 11</b> is a protein that in humans is encoded by the <i>IL11</i> gene.</p>",
                "thumbnail": null
            }
        ],
        "literature": {
            "PUB00013131": {
                "PMID": 9416001,
                "ISBN": null,
                "volume": "29",
                "issue": "8-9",
                "year": 1997,
                "title": "Interleukin-11.",
                "URL": null,
                "raw_pages": "1059-62",
                "medline_journal": "Int J Biochem Cell Biol",
                "ISO_journal": "Int. J. Biochem. Cell Biol.",
                "authors": [
                    "Leng SX",
                    "Elias JA."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S1357-2725(97)00017-4"
            }
        },
        "set_info": {
            "accession": "CL0053",
            "name": "4H_Cytokine"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 15,
            "interactions": 0,
            "matches": 705,
            "pathways": 0,
            "proteins": 695,
            "proteomes": 365,
            "sets": 1,
            "structural_models": {
                "alphafold": 623,
                "bfvd": 0
            },
            "structures": 8,
            "taxa": 1281
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 7,
            "alignment:full": 488
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "8dpv",
            "name": "The crystal structure of Interleukin-11, W147A mutant"
        }
    }
}