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{
    "metadata": {
        "accession": "PF06242",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR010421",
        "hierarchy": null,
        "name": {
            "name": "Transcriptional cell cycle regulator TrcR",
            "short": "TrcR"
        },
        "description": [
            {
                "text": "<p>This family represents a transcriptional cell cycle regulator (TrcR) found in Proteobacteria, mainly Alphaproteobacteria. It has been shown to associate with promoters and coding sequences in vivo in a rifampicin-dependent manner and to interact physically and genetically with RNA polymerase, resulting in the integration of cell cycle and antibiotic stress control with the general transcriptional machinery [[cite:PUB00098048]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00098048": {
                "PMID": 33602809,
                "ISBN": null,
                "volume": "118",
                "issue": "8",
                "year": 2021,
                "title": "The DUF1013 protein TrcR tracks with RNA polymerase to control the bacterial cell cycle and protect against antibiotics.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc Natl Acad Sci U S A",
                "authors": [
                    "Delaby M",
                    "Varesio LM",
                    "Degeorges L",
                    "Crosson S",
                    "Viollier PH."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 5,
            "interactions": 0,
            "matches": 2985,
            "pathways": 0,
            "proteins": 2985,
            "proteomes": 2467,
            "sets": 0,
            "structural_models": {
                "alphafold": 2229,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 3796
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 36,
            "alignment:full": 1510
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}