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{
"metadata": {
"accession": "PF05032",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR007727",
"hierarchy": null,
"name": {
"name": "Spo12 family",
"short": "Spo12"
},
"description": [
{
"text": "<p>This family of proteins includes Spo12 from S. cerevisiae [swissprot:P17123]. The Spo12 protein plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive [[cite:PUB00010231]]. Spo12 is a nuclear protein [[cite:PUB00010232]]. Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, that promotes Cdc14 release from the nucleolus during early anaphase [[cite:PUB00010233]]. The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12 [[cite:PUB00010233]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00010231": {
"PMID": 11729145,
"ISBN": null,
"volume": "159",
"issue": "3",
"year": 2001,
"title": "The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex.",
"URL": null,
"raw_pages": "965-80",
"medline_journal": "Genetics",
"ISO_journal": "Genetics",
"authors": [
"Shah R",
"Jensen S",
"Frenz LM",
"Johnson AL",
"Johnston LH."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=11729145"
},
"PUB00010232": {
"PMID": 11278742,
"ISBN": null,
"volume": "276",
"issue": "21",
"year": 2001,
"title": "Nuclear import of Spo12p, a protein essential for meiosis.",
"URL": null,
"raw_pages": "17712-7",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Chaves SR",
"Blobel G."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M010760200"
},
"PUB00010233": {
"PMID": 11832211,
"ISBN": null,
"volume": "108",
"issue": "2",
"year": 2002,
"title": "Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase.",
"URL": null,
"raw_pages": "207-20",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Stegmeier F",
"Visintin R",
"Amon A."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(02)00618-9"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 32,
"interactions": 0,
"matches": 1694,
"pathways": 0,
"proteins": 1693,
"proteomes": 1370,
"sets": 0,
"structural_models": {
"alphafold": 1475,
"bfvd": 0
},
"structures": 0,
"taxa": 3271
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 30,
"alignment:full": 1180
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
