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{
    "metadata": {
        "accession": "PF04925",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR007009",
        "hierarchy": null,
        "name": {
            "name": "SHQ1 protein, Shq1 domain",
            "short": "SHQ1"
        },
        "description": [
            {
                "text": "<p>This domain is found at the C-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ribosomal RNA and telomerase RNA processing and metabolism. This protein contains two domains: an N-terminal CS or HSP20-like domain ([pfam:PF21413]) and a C-terminal region called the Shq1 domain (this entry). This domain adopts a mostly helical structure that consists of 17 alpha-helices and two short beta-strands [[cite:PUB00065674],[cite:PUB00059551]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00059551": {
                "PMID": 22085966,
                "ISBN": null,
                "volume": "25",
                "issue": "22",
                "year": 2011,
                "title": "The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.",
                "URL": null,
                "raw_pages": "2398-408",
                "medline_journal": "Genes Dev",
                "ISO_journal": "Genes Dev.",
                "authors": [
                    "Walbott H",
                    "Machado-Pinilla R",
                    "Liger D",
                    "Blaud M",
                    "Rety S",
                    "Grozdanov PN",
                    "Godin K",
                    "van Tilbeurgh H",
                    "Varani G",
                    "Meier UT",
                    "Leulliot N."
                ],
                "DOI_URL": "http://dx.doi.org/10.1101/gad.176834.111"
            },
            "PUB00065674": {
                "PMID": 22117216,
                "ISBN": null,
                "volume": "30",
                "issue": "24",
                "year": 2011,
                "title": "Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.",
                "URL": null,
                "raw_pages": "5010-20",
                "medline_journal": "EMBO J",
                "ISO_journal": "EMBO J.",
                "authors": [
                    "Li S",
                    "Duan J",
                    "Li D",
                    "Ma S",
                    "Ye K."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/emboj.2011.427"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 58,
            "interactions": 0,
            "matches": 2932,
            "pathways": 0,
            "proteins": 2867,
            "proteomes": 1908,
            "sets": 0,
            "structural_models": {
                "alphafold": 2585,
                "bfvd": 0
            },
            "structures": 4,
            "taxa": 6049
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 57,
            "alignment:full": 1977
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3zuz",
            "name": "Structure of Shq1p C-terminal domain"
        }
    }
}