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{
"metadata": {
"accession": "PF03881",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR016477",
"hierarchy": null,
"name": {
"name": "Fructosamine kinase",
"short": "Fructosamin_kin"
},
"description": [
{
"text": "<p>This family includes eukaryotic fructosamine-3-kinase enzymes [[cite:PUB00008463]]. The family also includes bacterial members that have not been characterised but probably have a similar or identical function.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "Fructosamine_kinase_family",
"extract": "<p>In molecular biology the <b>fructosamine kinase family</b> is a family of enzymes. This family includes eukaryotic fructosamine-3-kinase enzymes which may initiate a process leading to the deglycation of fructoselysine and of glycated proteins and in the phosphorylation of 1-deoxy-1-morpholinofructose, fructoselysine, fructoseglycine, fructose and glycated lysozyme. The family also includes ketosamine-3-kinases (KT3K). Ketosamines derive from a non-enzymatic reaction between a sugar and a protein. Ketosamine-3-kinases (KT3K) catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degradation, and KT3K is thus thought to be involved in protein repair.</p>",
"thumbnail": null
}
],
"literature": {
"PUB00008463": {
"PMID": 11016445,
"ISBN": null,
"volume": "49",
"issue": "10",
"year": 2000,
"title": "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.",
"URL": null,
"raw_pages": "1627-34",
"medline_journal": "Diabetes",
"ISO_journal": "Diabetes",
"authors": [
"Delpierre G",
"Rider MH",
"Collard F",
"Stroobant V",
"Vanstapel F",
"Santos H",
"Van Schaftingen E."
],
"DOI_URL": "http://intl-diabetes.diabetesjournals.org/cgi/content/abstract/49/10/1627"
}
},
"set_info": {
"accession": "CL0016",
"name": "PKinase"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 159,
"interactions": 0,
"matches": 16168,
"pathways": 0,
"proteins": 15869,
"proteomes": 8623,
"sets": 1,
"structural_models": {
"alphafold": 12591,
"bfvd": 0
},
"structures": 10,
"taxa": 17463
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 19,
"alignment:full": 7927
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "9cx8",
"name": "Crystal structure of Human FN3K in apo-state"
}
}
}
