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{
    "metadata": {
        "accession": "PF02199",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR003119",
        "hierarchy": null,
        "name": {
            "name": "Saposin A-type domain",
            "short": "SapA"
        },
        "description": null,
        "wikipedia": [
            {
                "title": "Saposin_protein_domain",
                "extract": "<p>The <b>saposin domains</b> refers to two evolutionally-conserved protein domains found in saposin and related proteins (SAPLIP). Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes. They probably act by isolating the lipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four <i>Saposin-B domains</i>, yielding the active saposins after proteolytic cleavage, and two <i>Saposin-A domains</i> that are removed in the activation reaction.</p>",
                "thumbnail": null
            }
        ],
        "literature": null,
        "set_info": {
            "accession": "CL0707",
            "name": "Saposin_like"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 398,
            "interactions": 0,
            "matches": 6428,
            "pathways": 0,
            "proteins": 4380,
            "proteomes": 1157,
            "sets": 1,
            "structural_models": {
                "alphafold": 3950,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 4079
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 76,
            "alignment:full": 4293
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}