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{
"metadata": {
"accession": "PF01648",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR008278",
"hierarchy": null,
"name": {
"name": "4'-phosphopantetheinyl transferase superfamily",
"short": "ACPS"
},
"description": [
{
"text": "<p>Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of [pfam:PF00550]. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [[cite:PUB00002924]]. This superfamily consists of two subtypes: The ACPS type such as [swissprot:P24224] and the Sfp type such as [swissprot:P39135]. The structure of the Sfp type is known [[cite:PUB00011221]], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "Holo-(acyl-carrier-protein)_synthase",
"extract": "<p>In enzymology and molecular biology, a <b>holo-[acyl-carrier-protein] synthase</b> is an enzyme that catalyzes the chemical reaction:</p><dl><dd>CoA-[4'-phosphopantetheine] + apo-acyl carrier protein <span class=\"mwe-math-element mwe-math-element-inline\"><img src=\"https://wikimedia.org/api/rest_v1/media/math/render/svg/1c37b981df851b9e54e489e017b1481e37d418f3\" class=\"mwe-math-fallback-image-inline mw-invert skin-invert\" aria-hidden=\"true\" style=\"vertical-align:-0.338ex;width:2.324ex;height:1.843ex\" /></span> adenosine 3',5'-bisphosphate + holo-acyl carrier protein</dd></dl>",
"thumbnail": null
}
],
"literature": {
"PUB00011221": {
"PMID": 10581256,
"ISBN": null,
"volume": "18",
"issue": "23",
"year": 1999,
"title": "Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily.",
"URL": null,
"raw_pages": "6823-31",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Reuter K",
"Mofid MR",
"Marahiel MA",
"Ficner R."
],
"DOI_URL": "http://dx.doi.org/10.1093/emboj/18.23.6823"
},
"PUB00002924": {
"PMID": 7559576,
"ISBN": null,
"volume": "270",
"issue": "42",
"year": 1995,
"title": "Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase.",
"URL": null,
"raw_pages": "24658-61",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Lambalot RH",
"Walsh CT."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.270.42.24658"
},
"PUB00019094": {
"PMID": 8939709,
"ISBN": null,
"volume": "3",
"issue": "11",
"year": 1996,
"title": "A new enzyme superfamily - the phosphopantetheinyl transferases.",
"URL": null,
"raw_pages": "923-36",
"medline_journal": "Chem Biol",
"ISO_journal": "Chem. Biol.",
"authors": [
"Lambalot RH",
"Gehring AM",
"Flugel RS",
"Zuber P",
"LaCelle M",
"Marahiel MA",
"Reid R",
"Khosla C",
"Walsh CT."
],
"DOI_URL": "http://dx.doi.org/10.1016/S1074-5521(96)90181-7"
}
},
"set_info": {
"accession": "CL0670",
"name": "4PPT"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 348,
"interactions": 0,
"matches": 51752,
"pathways": 0,
"proteins": 51745,
"proteomes": 20259,
"sets": 1,
"structural_models": {
"alphafold": 37610,
"bfvd": 2
},
"structures": 107,
"taxa": 36900
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 143,
"alignment:full": 20469
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5xu7",
"name": "Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS)"
}
}
}
