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{
    "metadata": {
        "accession": "PTHR45859",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "panther",
        "member_databases": null,
        "integrated": "IPR051855",
        "hierarchy": null,
        "name": {
            "name": "Eukaryotic initiation factor 2B subunit beta",
            "short": "eIF2B_beta_subunit"
        },
        "description": [
            {
                "text": "This family of proteins functions as components of the translation initiation factor 2B (eIF2B) complex, which is responsible for the exchange of GDP for GTP on the eIF2 gamma subunit. This activity is crucial for the initiation of protein synthesis as it allows the formation of the eIF2-GTP-methionyl-initiator methionine tRNA complex necessary for the start of translation. The activity of these proteins is regulated by the phosphorylation status of the eIF2 alpha subunit; when eIF2 is phosphorylated, the exchange factor activity of the eIF2B complex is repressed, leading to a reduction in global protein synthesis. This serves as a regulatory mechanism during cellular stress responses. Some members of this family are also known to be activated by specific chemicals that can stimulate their activity regardless of the phosphorylation state of eIF2, thus influencing the integrated stress response.",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 4,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 4993,
            "pathways": 0,
            "proteins": 4993,
            "proteomes": 3223,
            "sets": 0,
            "structural_models": {
                "alphafold": 4433,
                "bfvd": 0
            },
            "structures": 35,
            "taxa": 9154
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0
        },
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}