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{
    "metadata": {
        "accession": "PTHR34719",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "panther",
        "member_databases": null,
        "integrated": "IPR050192",
        "hierarchy": null,
        "name": {
            "name": "Nickel-responsive transcriptional regulator",
            "short": "CopG/NikR_regulator"
        },
        "description": [
            {
                "text": "The CopG/NikR family of transcriptional regulators is involved in the response to intracellular nickel concentrations. Members of this family function as transcriptional repressors or regulators, with some specifically repressing the nikABCDE operon when intracellular nickel levels are excessive. This operon is typically associated with nickel uptake and transport, suggesting a role for these regulators in metal ion homeostasis. The activity of these proteins is indicative of a metal-dependent regulatory mechanism, where binding of nickel ions likely induces conformational changes that affect DNA binding and transcriptional repression.",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 2,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 4626,
            "pathways": 0,
            "proteins": 4626,
            "proteomes": 2262,
            "sets": 0,
            "structural_models": {
                "alphafold": 4050,
                "bfvd": 1
            },
            "structures": 26,
            "taxa": 5015
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0
        },
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3bkt",
            "name": "Copper-bound C-terminal Domain of NikR"
        }
    }
}