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{
    "metadata": {
        "accession": "PTHR21494",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "panther",
        "member_databases": null,
        "integrated": "IPR052586",
        "hierarchy": null,
        "name": {
            "name": "Activating signal cointegrator 1 complex subunit 2",
            "short": "ASCC2"
        },
        "description": [
            {
                "text": "The ASCC2 family comprises ubiquitin-binding proteins that play a crucial role in DNA repair and the ribosome quality control (RQC) pathway. Members of the family are involved in the rescue of stalled ribosomes and the degradation of nascent peptide chains during problematic translation. They function as part of the ASCC complex, recruiting other components such as ASCC3 and ALKBH3 to sites of DNA damage by binding to proteins with 'Lys-63'-linked polyubiquitin chains. Additionally, they are implicated in enhancing the transactivation of NF-kappa-B, SRF, and AP1. The family is characterized by the presence of a CUE domain that specifically binds RPS20/uS10 ubiquitinated by ZNF598, which is essential for the recruitment of the RQT complex on stalled ribosomes, leading to their disassembly.",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 2,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 5139,
            "pathways": 0,
            "proteins": 5139,
            "proteomes": 2762,
            "sets": 0,
            "structural_models": {
                "alphafold": 4418,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 7911
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0
        },
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}