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{
    "metadata": {
        "accession": "cd23817",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins",
            "short": "RWD-RWDD4"
        },
        "description": [
            {
                "text": "<p>RWDD4, also called protein FAM28A, is a target of the tumor suppressor MicroRNA (MiR)-506 in bladder cancer cells. Downregulation of RWDD4 suppresses bladder cancer cell proliferation, migration and invasion. RWDD4 has also been identified as a modifier of metastasis in human prostate cancer. [[cite:PUB00158478], [cite:PUB00158479]]</p>",
                "llm": false,
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                "updated": false
            }
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        "wikipedia": null,
        "literature": {
            "PUB00158479": {
                "PMID": 30655740,
                "ISBN": null,
                "volume": "17",
                "issue": "1",
                "year": 2019,
                "title": "MiR-506 inhibits cell proliferation, invasion, migration and epithelial-to-mesenchymal transition through targeting RWDD4 in human bladder cancer.",
                "URL": null,
                "raw_pages": "73-78",
                "medline_journal": "Oncol Lett",
                "ISO_journal": "Oncol Lett",
                "authors": [
                    "Hou Y."
                ],
                "DOI_URL": "https://doi.org/10.3892/ol.2018.9594"
            },
            "PUB00158478": {
                "PMID": 33447057,
                "ISBN": null,
                "volume": "14",
                "issue": null,
                "year": 2021,
                "title": "LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis.",
                "URL": null,
                "raw_pages": "157-164",
                "medline_journal": "Onco Targets Ther",
                "ISO_journal": "Onco Targets Ther",
                "authors": [
                    "Zheng Y",
                    "Xie J",
                    "Xu X",
                    "Yang X",
                    "Zhou Y",
                    "Yao Q",
                    "Xiong Y."
                ],
                "DOI_URL": "https://doi.org/10.2147/OTT.S278986"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1511,
            "pathways": 0,
            "proteins": 1511,
            "proteomes": 1038,
            "sets": 0,
            "structural_models": {
                "alphafold": 1393,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 3658
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}