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{
"metadata": {
"accession": "cd23728",
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"source_database": "cdd",
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"name": {
"name": "C2H2 zinc finger and Ribonuclease III domain of Kinetoplastid RNA Editing endonuclease 1 (KREN1)",
"short": "ZF_RNaseIII_KREN1"
},
"description": [
{
"text": "<p>KREN1 (KREPB1) is an RNase III family endonuclease of the RNA-editing catalytic complex (RECC) involved in U-insertion/deletion mRNA editing during kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. The RECC core complex comprises a U-insertion subcomplex (KRET2 TUTase, KREPA1 zinc-finger protein, and KREL2 RNA ligase), a U-deletion subcomplex (KREX2 exonuclease, KREPA2 zinc-finger protein, and KREL1 RNA ligase), and six structural and/or RNA-binding proteins (KREPA3, KREPA4, KREPA5, KREPA6, KREPB4, and KREPB5). This core complex interacts with one of three RNase III family endonucleases (KREN1, KREN2, and KREN3) that may partner with one or more partner protein(s) with divergent RNase III domains, such as KREN1/KREPB8, KREN2/KREPB7, KREN3/KREPB6. KREPB4-KREPB10 have divergent RNase III domains. RECC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and the RNA-editing substrate-binding complex (RESC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. [[cite:PUB00042707], [cite:PUB00157634], [cite:PUB00157635], [cite:PUB00157636], [cite:PUB00157638], [cite:PUB00157639], [cite:PUB00157640], [cite:PUB00157641], [cite:PUB00157642], [cite:PUB00157643]]</p>",
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"PUB00157636": {
"PMID": 12574127,
"ISBN": null,
"volume": "22",
"issue": "4",
"year": 2003,
"title": "Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria.",
"URL": null,
"raw_pages": "913-24",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J",
"authors": [
"Aphasizhev R",
"Aphasizheva I",
"Nelson RE",
"Gao G",
"Simpson AM",
"Kang X",
"Falick AM",
"Sbicego S",
"Simpson L."
],
"DOI_URL": "https://doi.org/10.1093/emboj/cdg083"
},
"PUB00157634": {
"PMID": 32191849,
"ISBN": null,
"volume": "36",
"issue": "4",
"year": 2020,
"title": "Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.",
"URL": null,
"raw_pages": "337-355",
"medline_journal": "Trends Parasitol",
"ISO_journal": "Trends Parasitol",
"authors": [
"Aphasizheva I",
"Alfonzo J",
"Carnes J",
"Cestari I",
"Cruz-Reyes J",
"Goringer HU",
"Hajduk S",
"Lukes J",
"Madison-Antenucci S",
"Maslov DA",
"McDermott SM",
"Ochsenreiter T",
"Read LK",
"Salavati R",
"Schnaufer A",
"Schneider A",
"Simpson L",
"Stuart K",
"Yurchenko V",
"Zhou ZH",
"Zikova A",
"Zhang L",
"Zimmer S",
"Aphasizhev R."
],
"DOI_URL": "https://doi.org/10.1016/j.pt.2020.01.006"
},
"PUB00157643": {
"PMID": 29359194,
"ISBN": null,
"volume": "3",
"issue": "1",
"year": 2018,
"title": "RNase III Domain of KREPB9 and KREPB10 Association with Editosomes in <i>Trypanosoma brucei</i>.",
"URL": null,
"raw_pages": "e00585-17",
"medline_journal": "mSphere",
"ISO_journal": "mSphere",
"authors": [
"Carnes J",
"McDermott SM",
"Stuart K."
],
"DOI_URL": "https://doi.org/10.1128/mSphereDirect.00585-17"
},
"PUB00157638": {
"PMID": 30213880,
"ISBN": null,
"volume": "362",
"issue": "6413",
"year": 2018,
"title": "Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.",
"URL": null,
"raw_pages": "eaau7735",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Ramrath DJF",
"Niemann M",
"Leibundgut M",
"Bieri P",
"Prange C",
"Horn EK",
"Leitner A",
"Boehringer D",
"Schneider A",
"Ban N."
],
"DOI_URL": "https://doi.org/10.1126/science.aau7735"
},
"PUB00157642": {
"PMID": 22184461,
"ISBN": null,
"volume": "18",
"issue": "2",
"year": 2012,
"title": "KREPB6, KREPB7, and KREPB8 are important for editing endonuclease function in Trypanosoma brucei.",
"URL": null,
"raw_pages": "308-20",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Guo X",
"Carnes J",
"Ernst NL",
"Winkler M",
"Stuart K."
],
"DOI_URL": "https://doi.org/10.1261/rna.029314.111"
},
"PUB00157635": {
"PMID": 28802260,
"ISBN": null,
"volume": "23",
"issue": "11",
"year": 2017,
"title": "The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.",
"URL": null,
"raw_pages": "1672-1684",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"McDermott SM",
"Stuart K."
],
"DOI_URL": "https://doi.org/10.1261/rna.062786.117"
},
"PUB00042707": {
"PMID": 12649499,
"ISBN": null,
"volume": "9",
"issue": "4",
"year": 2003,
"title": "Identification of novel components of Trypanosoma brucei editosomes.",
"URL": null,
"raw_pages": "484-92",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"Panigrahi AK",
"Schnaufer A",
"Ernst NL",
"Wang B",
"Carmean N",
"Salavati R",
"Stuart K."
],
"DOI_URL": "http://dx.doi.org/10.1261/rna.2194603"
},
"PUB00157639": {
"PMID": 33677542,
"ISBN": null,
"volume": "49",
"issue": "6",
"year": 2021,
"title": "Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10.",
"URL": null,
"raw_pages": "3557-3572",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Dubey AP",
"Tylec BL",
"McAdams NM",
"Sortino K",
"Read LK."
],
"DOI_URL": "https://doi.org/10.1093/nar/gkab129"
},
"PUB00157640": {
"PMID": 26370513,
"ISBN": null,
"volume": "35",
"issue": "23",
"year": 2015,
"title": "Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei.",
"URL": null,
"raw_pages": "3945-61",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"McDermott SM",
"Carnes J",
"Stuart K."
],
"DOI_URL": "https://doi.org/10.1128/MCB.00790-15"
},
"PUB00157641": {
"PMID": 31171708,
"ISBN": null,
"volume": "25",
"issue": "9",
"year": 2019,
"title": "Editosome RNase III domain interactions are essential for editing and differ between life cycle stages in <i>Trypanosoma brucei</i>.",
"URL": null,
"raw_pages": "1150-1163",
"medline_journal": "RNA",
"ISO_journal": "RNA",
"authors": [
"McDermott SM",
"Carnes J",
"Stuart K."
],
"DOI_URL": "https://doi.org/10.1261/rna.071258.119"
}
},
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"proteomes": 26,
"sets": 0,
"structural_models": {
"alphafold": 42,
"bfvd": 0
},
"structures": 0,
"taxa": 69
},
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"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
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}
}
