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{
"metadata": {
"accession": "cd22767",
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"source_database": "cdd",
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"integrated": "IPR049768",
"hierarchy": null,
"name": {
"name": "OTU (ovarian tumor) domain of Ubiquitin thioesterase ZRANB1 and similar proteins",
"short": "OTU_ZRANB1"
},
"description": [
{
"text": "<p>ZRANB1 is also called TRAF-binding domain-containing protein, Trabid, or zinc finger Ran-binding domain-containing protein 1. It is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin; it also cleaves 'Lys-63'-linked chains with less efficiency. ZRANB1 binds, deubiquitinates, and stabilizes EZH2, which is the catalytic component of the Polycomb repressive complex 2 (PRC2) that silences gene transcription by methylating histone H3 at lysine 27 and is mutated or highly expressed in many types of cancer, including lymphoma, melanoma, prostate cancer, ovarian cancer, and breast cancer. Drosophila Trabid interacts with TGF-beta Activating Kinase 1 (TAK1), which triggers both immunity and apoptosis, resulting in reduced immune signaling output and K63-linked ubiquitination. ZRANB1 belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. ZRANB1 does not contain the conserved aspartate, and uses cysteine and histidine as a catalytic dyad. It is classified as a family C64 cysteine protease by MEROPS. [[cite:PUB00091518], [cite:PUB00076543], [cite:PUB00150475], [cite:PUB00150476], [cite:PUB00150477], [cite:PUB00150478], [cite:PUB00150489], [cite:PUB00150439], [cite:PUB00150743]]</p>",
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"PUB00150489": {
"PMID": 29748605,
"ISBN": null,
"volume": "9",
"issue": "5",
"year": 2018,
"title": "Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.",
"URL": null,
"raw_pages": "540",
"medline_journal": "Cell Death Dis",
"ISO_journal": "Cell Death Dis",
"authors": [
"Wang JJ",
"Shan K",
"Liu BH",
"Liu C",
"Zhou RM",
"Li XM",
"Dong R",
"Zhang SJ",
"Zhang SH",
"Wu JH",
"Yan B."
],
"DOI_URL": null
},
"PUB00091518": {
"PMID": 22157957,
"ISBN": null,
"volume": "19",
"issue": "1",
"year": 2011,
"title": "An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.",
"URL": null,
"raw_pages": "62-71",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Licchesi JD",
"Mieszczanek J",
"Mevissen TE",
"Rutherford TJ",
"Akutsu M",
"Virdee S",
"El Oualid F",
"Chin JW",
"Ovaa H",
"Bienz M",
"Komander D."
],
"DOI_URL": "https://doi.org/10.1038/nsmb.2169"
},
"PUB00150743": {
"PMID": 23743024,
"ISBN": null,
"volume": "95",
"issue": "2",
"year": 2013,
"title": "UBE3B and ZRANB1 polymorphisms and transcript abundance are associated with water holding capacity of porcine M. longissimus dorsi.",
"URL": null,
"raw_pages": "166-72",
"medline_journal": "Meat Sci",
"ISO_journal": "Meat Sci",
"authors": [
"Huynh TP",
"Murani E",
"Maak S",
"Ponsuksili S",
"Wimmers K."
],
"DOI_URL": null
},
"PUB00150476": {
"PMID": 18281465,
"ISBN": null,
"volume": "22",
"issue": "4",
"year": 2008,
"title": "Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.",
"URL": null,
"raw_pages": "528-42",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Tran H",
"Hamada F",
"Schwarz-Romond T",
"Bienz M."
],
"DOI_URL": null
},
"PUB00076543": {
"PMID": 23827681,
"ISBN": null,
"volume": "154",
"issue": "1",
"year": 2013,
"title": "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.",
"URL": null,
"raw_pages": "169-84",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Mevissen TE",
"Hospenthal MK",
"Geurink PP",
"Elliott PR",
"Akutsu M",
"Arnaudo N",
"Ekkebus R",
"Kulathu Y",
"Wauer T",
"El Oualid F",
"Freund SM",
"Ovaa H",
"Komander D."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2013.05.046"
},
"PUB00150477": {
"PMID": 24586180,
"ISBN": null,
"volume": "10",
"issue": "2",
"year": 2014,
"title": "Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span.",
"URL": null,
"raw_pages": "e1004117",
"medline_journal": "PLoS Genet",
"ISO_journal": "PLoS Genet",
"authors": [
"Fernando MD",
"Kounatidis I",
"Ligoxygakis P."
],
"DOI_URL": null
},
"PUB00150478": {
"PMID": 29669287,
"ISBN": null,
"volume": "23",
"issue": "3",
"year": 2018,
"title": "ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.",
"URL": null,
"raw_pages": "823-837",
"medline_journal": "Cell Rep",
"ISO_journal": "Cell Rep",
"authors": [
"Zhang P",
"Xiao Z",
"Wang S",
"Zhang M",
"Wei Y",
"Hang Q",
"Kim J",
"Yao F",
"Rodriguez-Aguayo C",
"Ton BN",
"Lee M",
"Wang Y",
"Zhou Z",
"Zeng L",
"Hu X",
"Lawhon SE",
"Siverly AN",
"Su X",
"Li J",
"Xie X",
"Cheng X",
"Liu LC",
"Chang HW",
"Chiang SF",
"Lopez-Berestein G",
"Sood AK",
"Chen J",
"You MJ",
"Sun SC",
"Liang H",
"Huang Y",
"Yang X",
"Sun D",
"Sun Y",
"Hung MC",
"Ma L."
],
"DOI_URL": null
},
"PUB00150439": {
"PMID": 26808229,
"ISBN": null,
"volume": "17",
"issue": "3",
"year": 2016,
"title": "Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid.",
"URL": null,
"raw_pages": "259-68",
"medline_journal": "Nat Immunol",
"ISO_journal": "Nat Immunol",
"authors": [
"Jin J",
"Xie X",
"Xiao Y",
"Hu H",
"Zou Q",
"Cheng X",
"Sun SC."
],
"DOI_URL": null
},
"PUB00150475": {
"PMID": 26882254,
"ISBN": null,
"volume": "17",
"issue": "3",
"year": 2016,
"title": "Trabid epigenetically drives expression of IL-12 and IL-23.",
"URL": null,
"raw_pages": "227-8",
"medline_journal": "Nat Immunol",
"ISO_journal": "Nat Immunol",
"authors": [
"Afonina IS",
"Beyaert R."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl45892",
"name": "OTU"
},
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"counters": {
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"matches": 1705,
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"proteins": 1705,
"proteomes": 987,
"sets": 1,
"structural_models": {
"alphafold": 1557,
"bfvd": 0
},
"structures": 1,
"taxa": 3455
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
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}
}
