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{
"metadata": {
"accession": "cd22608",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "Pseudocerastes persicus trypsin inhibitor (PPTI), Kunitz-type serine protease inhibitor bitisilin, and similar proteins",
"short": "Kunitz_PPTI-like"
},
"description": [
{
"text": "<p>This group contains Pseudocerastes persicus trypsin inhibitor (PPTI), Bitis gabonica Kunitz-type serine protease inhibitor bitisilin-1 (BG-11), -2 (BG-15) and -3 (two-Kunitz protease inhibitor), Oxyuranus scutellatus scutellatus taicatoxin, and serine protease inhibitor component (TSPI, also called venom protease inhibitor 1 or venom protease inhibitor 2), among others. PPTI from P. persicus venom shows inhibitory effect against trypsin proteolytic activity and has similarities to dendrotoxins (DTXs), with corresponding functionally important residues. Studies have shown the ability of PPTI to inhibit voltage-gated potassium channels, and consequently have dual functionality. Bitilisins 1, 2, and 3 are serine protease inhibitors expressed in snake venom glands; bitsilin-3 consists of two Kunitz protease inhibitor domains. Taicatoxin inhibits trypsin, tissue kallikrein, elastase, plasmin and factor Xa, and is also known to block the voltage-dependent L-type calcium channels from the heart, and the small conductance calcium-activated potassium channels (KCa) in chromaffin cells and in the brain. The structures of these Kunitz-type proteins are similar to other Kunitz-type proteinase inhibitors such as BPTI (bovine pancreatic trypsin inhibitor), showing an alpha/beta fold with irregular secondary structure stabilized by three disulfide bonds. [[cite:PUB00150560], [cite:PUB00150561], [cite:PUB00150562], [cite:PUB00110551], [cite:PUB00000032], [cite:PUB00005362], [cite:PUB00071166], [cite:PUB00110546]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00110551": {
"PMID": 2893290,
"ISBN": null,
"volume": "331",
"issue": "6156",
"year": 1988,
"title": "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.",
"URL": null,
"raw_pages": "528-30",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Tanzi RE",
"McClatchey AI",
"Lamperti ED",
"Villa-Komaroff L",
"Gusella JF",
"Neve RL."
],
"DOI_URL": null
},
"PUB00000032": {
"PMID": 6996568,
"ISBN": null,
"volume": "49",
"issue": null,
"year": 1980,
"title": "Protein inhibitors of proteinases.",
"URL": null,
"raw_pages": "593-626",
"medline_journal": "Annu Rev Biochem",
"ISO_journal": "Annu. Rev. Biochem.",
"authors": [
"Laskowski M Jr",
"Kato I."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev.bi.49.070180.003113"
},
"PUB00150562": {
"PMID": 18096037,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2007,
"title": "The venom gland transcriptome of the Desert Massasauga rattlesnake (Sistrurus catenatus edwardsii): towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea).",
"URL": null,
"raw_pages": "115",
"medline_journal": "BMC Mol Biol",
"ISO_journal": "BMC Mol Biol",
"authors": [
"Pahari S",
"Mackessy SP",
"Kini RM."
],
"DOI_URL": null
},
"PUB00005362": {
"PMID": 1703675,
"ISBN": null,
"volume": "15",
"issue": "11",
"year": 1990,
"title": "Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily.",
"URL": null,
"raw_pages": "435-9",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Salier JP."
],
"DOI_URL": "http://dx.doi.org/10.1016/0968-0004(90)90282-G"
},
"PUB00071166": {
"PMID": 8670091,
"ISBN": null,
"volume": "315 ( Pt 1)",
"issue": null,
"year": 1996,
"title": "The inter-alpha-inhibitor family: from structure to regulation.",
"URL": null,
"raw_pages": "1-9",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Salier JP",
"Rouet P",
"Raguenez G",
"Daveau M."
],
"DOI_URL": null
},
"PUB00150561": {
"PMID": 31261722,
"ISBN": null,
"volume": "9",
"issue": "7",
"year": 2019,
"title": "A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis. ",
"URL": null,
"raw_pages": "E254",
"medline_journal": "Biomolecules",
"ISO_journal": "Biomolecules",
"authors": [
"Dong Y",
"Shi D",
"Ying Y",
"Xi X",
"Chen X",
"Wang L",
"Zhou M",
"Wu Q",
"Ma C",
"Chen T."
],
"DOI_URL": null
},
"PUB00110546": {
"PMID": 2893289,
"ISBN": null,
"volume": "331",
"issue": "6156",
"year": 1988,
"title": "A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.",
"URL": null,
"raw_pages": "525-7",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Ponte P",
"Gonzalez-DeWhitt P",
"Schilling J",
"Miller J",
"Hsu D",
"Greenberg B",
"Davis K",
"Wallace W",
"Lieberburg I",
"Fuller F."
],
"DOI_URL": null
},
"PUB00150560": {
"PMID": 30973886,
"ISBN": null,
"volume": "14",
"issue": "4",
"year": 2019,
"title": "Structural characterization of PPTI, a kunitz-type protein from the venom of Pseudocerastes persicus.",
"URL": null,
"raw_pages": "e0214657",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Banijamali SE",
"Amininasab M",
"Zaeifi D."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl00101",
"name": "Kunitz-type"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 79,
"pathways": 0,
"proteins": 77,
"proteomes": 12,
"sets": 1,
"structural_models": {
"alphafold": 70,
"bfvd": 0
},
"structures": 1,
"taxa": 116
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
