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{
"metadata": {
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"name": {
"name": "first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins",
"short": "DSRM_ILF3_rpt1"
},
"description": [
{
"text": "<p>ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. [[cite:PUB00108292], [cite:PUB00149997], [cite:PUB00108293], [cite:PUB00108294], [cite:PUB00108295], [cite:PUB00108296], [cite:PUB00108297], [cite:PUB00108298], [cite:PUB00108299], [cite:PUB00108300], [cite:PUB00090426], [cite:PUB00108301], [cite:PUB00108302], [cite:PUB00108303], [cite:PUB00108304], [cite:PUB00101619], [cite:PUB00108305], [cite:PUB00108306], [cite:PUB00061746], [cite:PUB00108307], [cite:PUB00068832], [cite:PUB00108308]]</p>",
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"authors": [
"Jonson L",
"Vikesaa J",
"Krogh A",
"Nielsen LK",
"Hansen Tv",
"Borup R",
"Johnsen AH",
"Christiansen J",
"Nielsen FC."
],
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"issue": "29",
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"title": "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.",
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"medline_journal": "J Biol Chem",
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"authors": [
"Patel RC",
"Vestal DJ",
"Xu Z",
"Bandyopadhyay S",
"Guo W",
"Erme SM",
"Williams BR",
"Sen GC."
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"title": "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.",
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"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
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"Ulke-Lemee A",
"Trinkle-Mulcahy L",
"Chaulk S",
"Bernstein NK",
"Morrice N",
"Glover M",
"Lamond AI",
"Moorhead GB."
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"title": "Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.",
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"Weidensdorfer D",
"Stohr N",
"Baude A",
"Lederer M",
"Kohn M",
"Schierhorn A",
"Buchmeier S",
"Wahle E",
"Huttelmaier S."
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"title": "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.",
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"raw_pages": "34598-604",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Satoh M",
"Shaheen VM",
"Kao PN",
"Okano T",
"Shaw M",
"Yoshida H",
"Richards HB",
"Reeves WH."
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"title": "The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.",
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"authors": [
"Wandrey F",
"Montellese C",
"Koos K",
"Badertscher L",
"Bammert L",
"Cook AG",
"Zemp I",
"Horvath P",
"Kutay U."
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"medline_journal": "Mol Genet Metab",
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"Xu YH",
"Grabowski GA."
],
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"volume": "71",
"issue": "2",
"year": 2001,
"title": "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13.",
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"raw_pages": "256-9",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Saunders LR",
"Jurecic V",
"Barber GN."
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"volume": "279",
"issue": "2",
"year": 2004,
"title": "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3.",
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"raw_pages": "884-91",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Gwizdek C",
"Ossareh-Nazari B",
"Brownawell AM",
"Evers S",
"Macara IG",
"Dargemont C."
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"volume": "261",
"issue": "2",
"year": 2000,
"title": "Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene.",
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"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Duchange N",
"Pidoux J",
"Camus E",
"Sauvaget D."
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"year": 2010,
"title": "Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.",
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"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Harashima A",
"Guettouche T",
"Barber GN."
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"issue": "1",
"year": 2002,
"title": "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.",
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"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Reichman TW",
"Muniz LC",
"Mathews MB."
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"issue": "2",
"year": 2017,
"title": "Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection.",
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"medline_journal": "Mol Cell",
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"authors": [
"Li X",
"Liu CX",
"Xue W",
"Zhang Y",
"Jiang S",
"Yin QF",
"Wei J",
"Yao RW",
"Yang L",
"Chen LL."
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"year": 1994,
"title": "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.",
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"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Kao PN",
"Chen L",
"Brock G",
"Ng J",
"Kenny J",
"Smith AJ",
"Corthesy B."
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"title": "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.",
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"medline_journal": "EMBO Rep",
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"Hock J",
"Weinmann L",
"Ender C",
"Rudel S",
"Kremmer E",
"Raabe M",
"Urlaub H",
"Meister G."
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"medline_journal": "Mol Cell",
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"authors": [
"Tran H",
"Schilling M",
"Wirbelauer C",
"Hess D",
"Nagamine Y."
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"issue": "34",
"year": 2001,
"title": "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.",
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"raw_pages": "32300-12",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Saunders LR",
"Perkins DJ",
"Balachandran S",
"Michaels R",
"Ford R",
"Mayeda A",
"Barber GN."
],
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"volume": "24",
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"year": 2004,
"title": "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.",
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"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Chen T",
"Brownawell AM",
"Macara IG."
],
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"issue": "4",
"year": 2016,
"title": "Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.",
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"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Jayachandran U",
"Grey H",
"Cook AG."
],
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},
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"volume": "275",
"issue": "26",
"year": 2000,
"title": "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.",
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"raw_pages": "19866-76",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Tang J",
"Kao PN",
"Herschman HR."
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"title": "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.",
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"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Ting NS",
"Kao PN",
"Chan DW",
"Lintott LG",
"Lees-Miller SP."
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"title": "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.",
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"medline_journal": "J Cell Biol",
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"Brownawell AM",
"Macara IG."
],
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