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{
"metadata": {
"accession": "cd19367",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "TenA_C family similar to the C-terminal TenA_C domain of Saccharomyces cerevisiae THI20 protein",
"short": "TenA_C_ScTHI20-like"
},
"description": [
{
"text": "<p>This TenA family belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. Saccharomyces cerevisiae THI20 includes a C-terminal tetrameric TenA-like domain fused to an N-terminal HMP kinase/HMP-P kinase (ThiD-like) domain, and participates in thiamin biosynthesis, degradation and salvage; the TenA-like domain catalyzes the production of HMP from thiamin degradation products (salvage). A majority of this family are single-domain TenA_C- like proteins; some however have additional domains such as a ThiD domain. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect. [[cite:PUB00064918], [cite:PUB00108479], [cite:PUB00070662], [cite:PUB00108053], [cite:PUB00108054], [cite:PUB00074296], [cite:PUB00108480], [cite:PUB00074293]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00108479": {
"PMID": 21904031,
"ISBN": null,
"volume": "67",
"issue": "Pt 9",
"year": 2011,
"title": "Structure of trifunctional THI20 from yeast.",
"URL": null,
"raw_pages": "784-91",
"medline_journal": "Acta Crystallogr D Biol Crystallogr",
"ISO_journal": "Acta Crystallogr D Biol Crystallogr",
"authors": [
"French JB",
"Begley TP",
"Ealick SE."
],
"DOI_URL": null
},
"PUB00108053": {
"PMID": 17637774,
"ISBN": null,
"volume": "3",
"issue": "8",
"year": 2007,
"title": "At the crossroad of thiamine degradation and biosynthesis.",
"URL": null,
"raw_pages": "454-5",
"medline_journal": "Nat Chem Biol",
"ISO_journal": "Nat Chem Biol",
"authors": [
"Bettendorff L."
],
"DOI_URL": null
},
"PUB00064918": {
"PMID": 18028398,
"ISBN": null,
"volume": "8",
"issue": "2",
"year": 2008,
"title": "Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "266-75",
"medline_journal": "FEMS Yeast Res",
"ISO_journal": "FEMS Yeast Res.",
"authors": [
"Onozuka M",
"Konno H",
"Kawasaki Y",
"Akaji K",
"Nosaka K."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1567-1364.2007.00333.x"
},
"PUB00108480": {
"PMID": 10383756,
"ISBN": null,
"volume": "32",
"issue": "6",
"year": 1999,
"title": "Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway.",
"URL": null,
"raw_pages": "1140-52",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol Microbiol",
"authors": [
"Llorente B",
"Fairhead C",
"Dujon B."
],
"DOI_URL": null
},
"PUB00108054": {
"PMID": 29018119,
"ISBN": null,
"volume": "8",
"issue": "5",
"year": 2017,
"title": "Globally Important Haptophyte Algae Use Exogenous Pyrimidine Compounds More Efficiently than Thiamin. ",
"URL": null,
"raw_pages": "e01459-17",
"medline_journal": "mBio",
"ISO_journal": "mBio",
"authors": [
"Gutowska MA",
"Shome B",
"Sudek S",
"McRose DL",
"Hamilton M",
"Giovannoni SJ",
"Begley TP",
"Worden AZ."
],
"DOI_URL": null
},
"PUB00070662": {
"PMID": 17618314,
"ISBN": null,
"volume": "3",
"issue": "8",
"year": 2007,
"title": "A new thiamin salvage pathway.",
"URL": null,
"raw_pages": "492-7",
"medline_journal": "Nat Chem Biol",
"ISO_journal": "Nat. Chem. Biol.",
"authors": [
"Jenkins AH",
"Schyns G",
"Potot S",
"Sun G",
"Begley TP."
],
"DOI_URL": "http://dx.doi.org/10.1038/nchembio.2007.13"
},
"PUB00074296": {
"PMID": 25014715,
"ISBN": null,
"volume": "463",
"issue": "1",
"year": 2014,
"title": "Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine.",
"URL": null,
"raw_pages": "145-55",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Zallot R",
"Yazdani M",
"Goyer A",
"Ziemak MJ",
"Guan JC",
"McCarty DR",
"de Crecy-Lagard V",
"Gerdes S",
"Garrett TJ",
"Benach J",
"Hunt JF",
"Shintani DK",
"Hanson AD."
],
"DOI_URL": "http://dx.doi.org/10.1042/BJ20140522"
},
"PUB00074293": {
"PMID": 9419250,
"ISBN": null,
"volume": "45",
"issue": "6",
"year": 1997,
"title": "ThiD-TenA: a gene pair fusion in eukaryotes.",
"URL": null,
"raw_pages": "708-11",
"medline_journal": "J Mol Evol",
"ISO_journal": "J. Mol. Evol.",
"authors": [
"Ouzounis CA",
"Kyrpides NC."
],
"DOI_URL": "http://dx.doi.org/10.1007/PL00013145"
}
},
"set_info": {
"accession": "cl38925",
"name": "TenA_PqqC-like"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3500,
"pathways": 0,
"proteins": 3500,
"proteomes": 2563,
"sets": 1,
"structural_models": {
"alphafold": 2765,
"bfvd": 0
},
"structures": 2,
"taxa": 4910
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3mvu",
"name": "Crystal structure of a TenA family transcription regulator (TM1040_3656) from SILICIBACTER SP. TM1040 at 1.80 A resolution"
}
}
}
