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"metadata": {
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"name": {
"name": "Wnt domain found in protein Wnt-5b and similar proteins",
"short": "Wnt_Wnt5b"
},
"description": [
{
"text": "<p>Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection. [[cite:PUB00060589], [cite:PUB00144719], [cite:PUB00108499], [cite:PUB00108500], [cite:PUB00144720], [cite:PUB00144721], [cite:PUB00144722], [cite:PUB00144723], [cite:PUB00144724], [cite:PUB00144725], [cite:PUB00144726], [cite:PUB00144727]]</p>",
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"PUB00144719": {
"PMID": 27126693,
"ISBN": null,
"volume": "48",
"issue": "2",
"year": 2016,
"title": "Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD.",
"URL": null,
"raw_pages": "504-15",
"medline_journal": "Eur Respir J",
"ISO_journal": "Eur Respir J",
"authors": [
"Heijink IH",
"de Bruin HG",
"Dennebos R",
"Jonker MR",
"Noordhoek JA",
"Brandsma CA",
"van den Berge M",
"Postma DS."
],
"DOI_URL": null
},
"PUB00144722": {
"PMID": 27762090,
"ISBN": null,
"volume": "108",
"issue": "1",
"year": 2017,
"title": "Wnt5b-associated exosomes promote cancer cell migration and proliferation.",
"URL": null,
"raw_pages": "42-52",
"medline_journal": "Cancer Sci",
"ISO_journal": "Cancer Sci",
"authors": [
"Harada T",
"Yamamoto H",
"Kishida S",
"Kishida M",
"Awada C",
"Takao T",
"Kikuchi A."
],
"DOI_URL": null
},
"PUB00108499": {
"PMID": 27036869,
"ISBN": null,
"volume": "310",
"issue": "11",
"year": 2016,
"title": "Noncanonical WNT-5B signaling induces inflammatory responses in human lung fibroblasts.",
"URL": null,
"raw_pages": "L1166-76",
"medline_journal": "Am J Physiol Lung Cell Mol Physiol",
"ISO_journal": "Am J Physiol Lung Cell Mol Physiol",
"authors": [
"van Dijk EM",
"Menzen MH",
"Spanjer AI",
"Middag LD",
"Brandsma CA",
"Gosens R."
],
"DOI_URL": null
},
"PUB00144720": {
"PMID": 29325710,
"ISBN": null,
"volume": "74",
"issue": null,
"year": 2018,
"title": "Wnt5b regulates apoptosis in Litopenaeus vannamei against white spot syndrome virus.",
"URL": null,
"raw_pages": "318-324",
"medline_journal": "Fish Shellfish Immunol",
"ISO_journal": "Fish Shellfish Immunol",
"authors": [
"Wang C",
"Ruan L",
"Shi H",
"Xu X."
],
"DOI_URL": null
},
"PUB00108500": {
"PMID": 18336582,
"ISBN": null,
"volume": "50",
"issue": "4",
"year": 2008,
"title": "Analysis of the expression and function of Wnt-5a and Wnt-5b in developing and regenerating axolotl (Ambystoma mexicanum) limbs.",
"URL": null,
"raw_pages": "289-97",
"medline_journal": "Dev Growth Differ",
"ISO_journal": "Dev Growth Differ",
"authors": [
"Ghosh S",
"Roy S",
"Seguin C",
"Bryant SV",
"Gardiner DM."
],
"DOI_URL": null
},
"PUB00144723": {
"PMID": 27593938,
"ISBN": null,
"volume": "36",
"issue": "11",
"year": 2017,
"title": "Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells.",
"URL": null,
"raw_pages": "1503-1515",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Wang SH",
"Chang JS",
"Hsiao JR",
"Yen YC",
"Jiang SS",
"Liu SH",
"Chen YL",
"Shen YY",
"Chang JY",
"Chen YW."
],
"DOI_URL": null
},
"PUB00144727": {
"PMID": 24220306,
"ISBN": null,
"volume": "44",
"issue": "1",
"year": 2014,
"title": "Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.",
"URL": null,
"raw_pages": "59-68",
"medline_journal": "Int J Oncol",
"ISO_journal": "Int J Oncol",
"authors": [
"Takeshita A",
"Iwai S",
"Morita Y",
"Niki-Yonekawa A",
"Hamada M",
"Yura Y."
],
"DOI_URL": null
},
"PUB00144726": {
"PMID": 21413026,
"ISBN": null,
"volume": "226",
"issue": "6",
"year": 2011,
"title": "Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.",
"URL": null,
"raw_pages": "1683-93",
"medline_journal": "J Cell Physiol",
"ISO_journal": "J Cell Physiol",
"authors": [
"Bradley EW",
"Drissi MH."
],
"DOI_URL": null
},
"PUB00144724": {
"PMID": 27287801,
"ISBN": null,
"volume": "143",
"issue": "14",
"year": 2016,
"title": "Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis.",
"URL": null,
"raw_pages": "2541-7",
"medline_journal": "Development",
"ISO_journal": "Development",
"authors": [
"Rochard L",
"Monica SD",
"Ling IT",
"Kong Y",
"Roberson S",
"Harland R",
"Halpern M",
"Liao EC."
],
"DOI_URL": null
},
"PUB00144725": {
"PMID": 27121420,
"ISBN": null,
"volume": "36",
"issue": "1",
"year": 2016,
"title": "Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway.",
"URL": null,
"raw_pages": "23-30",
"medline_journal": "Oncol Rep",
"ISO_journal": "Oncol Rep",
"authors": [
"Zhang Y",
"Lin L",
"Jin Y",
"Lin Y",
"Cao Y",
"Zheng C."
],
"DOI_URL": null
},
"PUB00060589": {
"PMID": 11445850,
"ISBN": null,
"volume": "19",
"issue": "2",
"year": 2001,
"title": "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region.",
"URL": null,
"raw_pages": "347-51",
"medline_journal": "Int J Oncol",
"ISO_journal": "Int. J. Oncol.",
"authors": [
"Saitoh T",
"Katoh M."
],
"DOI_URL": null
},
"PUB00144721": {
"PMID": 28078366,
"ISBN": null,
"volume": "100",
"issue": "3",
"year": 2017,
"title": "Genetic Screening of WNT4 and WNT5B in Two Populations with Deviating Bone Mineral Densities.",
"URL": null,
"raw_pages": "244-249",
"medline_journal": "Calcif Tissue Int",
"ISO_journal": "Calcif Tissue Int",
"authors": [
"Hendrickx G",
"Boudin E",
"Steenackers E",
"Nielsen TL",
"Andersen M",
"Brixen K",
"Van Hul W."
],
"DOI_URL": null
}
},
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"name": "Wnt"
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