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{
"text": "<p>EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics. [[cite:PUB00107047], [cite:PUB00091176], [cite:PUB00091377], [cite:PUB00091541], [cite:PUB00149731], [cite:PUB00149732], [cite:PUB00107030], [cite:PUB00060504], [cite:PUB00107046], [cite:PUB00107045], [cite:PUB00107044], [cite:PUB00107043], [cite:PUB00107041], [cite:PUB00107039], [cite:PUB00107042], [cite:PUB00107040], [cite:PUB00107038], [cite:PUB00107037], [cite:PUB00107035], [cite:PUB00107036], [cite:PUB00033453], [cite:PUB00107034], [cite:PUB00107033]]</p>",
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"Milyavsky M",
"Shats I",
"Erez N",
"Goldfinger N",
"Rotter V."
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"Helin K."
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"Nasveschuk CG",
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"Balasubramanian S",
"Zhao F",
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"Lee C",
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"Cummings RT",
"Normant E",
"Bellon SF",
"Albrecht BK",
"Harmange JC",
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"Audia JE",
"Zhang Y",
"Justin N",
"Chen S",
"Wilson JR",
"Gamblin SJ."
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"Della Pietra A 3rd",
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"Creasy CL."
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"authors": [
"Cha TL",
"Zhou BP",
"Xia W",
"Wu Y",
"Yang CC",
"Chen CT",
"Ping B",
"Otte AP",
"Hung MC."
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"authors": [
"Martin C",
"Cao R",
"Zhang Y."
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"Zhan SH",
"Bulman DE",
"Fejes AP",
"Moore R",
"Mungall AJ",
"Eydoux P",
"Babul-Hirji R",
"An J",
"Marra MA; FORGE Canada Consortium",
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"Bingham P",
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"Diehl W",
"Grable N",
"Kung PP",
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"Yu X",
"Stewart AE."
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"Brenner C",
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"Fraga M",
"Didelot C",
"Morey L",
"Van Eynde A",
"Bernard D",
"Vanderwinden JM",
"Bollen M",
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"de Launoit Y",
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"Xia L",
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"authors": [
"Bratkowski M",
"Yang X",
"Liu X."
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"Etchegaray JP",
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"Weaver DR",
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"Reppert SM."
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"Vargas M",
"Hamer KM",
"den Blaauwen JL",
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"Schweizer D",
"Jenuwein T",
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"authors": [
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"Zeng H",
"Dong A",
"Li F",
"He H",
"Senisterra G",
"Seitova A",
"Duan S",
"Brown PJ",
"Vedadi M",
"Arrowsmith CH",
"Schapira M."
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