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{
"metadata": {
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"name": {
"name": "basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins",
"short": "bHLHzip_USF1"
},
"description": [
{
"text": "<p>USF1, also termed Class B basic helix-loop-helix protein 11 (bHLHb11), or major late transcription factor 1, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. It is ubiquitously expressed and involved in the transcription activation of various functional genes implicated in lipid and glucose metabolism, stress response, immune response, cell cycle control and tumour suppression. USF-1 recruits chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. Genetic polymorphisms of USF1 are associated with some metabolic and cardiovascular diseases, like diabetes, atherosclerosis, coronary artery calcifications and familial combined hyperlipidaemia (FCHL). [[cite:PUB00144280], [cite:PUB00144527], [cite:PUB00014878], [cite:PUB00144528], [cite:PUB00144529], [cite:PUB00144530], [cite:PUB00144531], [cite:PUB00144532]]</p>",
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"literature": {
"PUB00144530": {
"PMID": 26052935,
"ISBN": null,
"volume": "84",
"issue": "4",
"year": 2016,
"title": "Association between single nucleotide polymorphisms of upstream transcription factor 1 (USF1) and susceptibility to papillary thyroid cancer.",
"URL": null,
"raw_pages": "564-70",
"medline_journal": "Clin Endocrinol (Oxf)",
"ISO_journal": "Clin Endocrinol (Oxf)",
"authors": [
"Yuan Q",
"Bu Q",
"Li G",
"Zhang J",
"Cui T",
"Zhu R",
"Mu D."
],
"DOI_URL": null
},
"PUB00014878": {
"PMID": 8306960,
"ISBN": null,
"volume": "13",
"issue": "1",
"year": 1994,
"title": "Structure and function of the b/HLH/Z domain of USF.",
"URL": null,
"raw_pages": "180-9",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Ferre-D'Amare AR",
"Pognonec P",
"Roeder RG",
"Burley SK."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8306960"
},
"PUB00144528": {
"PMID": 14573800,
"ISBN": null,
"volume": "84",
"issue": "Pt 11",
"year": 2003,
"title": "Transcription factor USF, expressed during the entire phase of varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication.",
"URL": null,
"raw_pages": "2957-2967",
"medline_journal": "J Gen Virol",
"ISO_journal": "J Gen Virol",
"authors": [
"Rahaus M",
"Desloges N",
"Yang M",
"Ruyechan WT",
"Wolff MH."
],
"DOI_URL": null
},
"PUB00144280": {
"PMID": 16162174,
"ISBN": null,
"volume": "18",
"issue": "5",
"year": 2005,
"title": "Upstream stimulating factors: highly versatile stress-responsive transcription factors.",
"URL": null,
"raw_pages": "337-48",
"medline_journal": "Pigment Cell Res",
"ISO_journal": "Pigment Cell Res",
"authors": [
"Corre S",
"Galibert MD."
],
"DOI_URL": null
},
"PUB00144527": {
"PMID": 14991056,
"ISBN": null,
"volume": "36",
"issue": "4",
"year": 2004,
"title": "Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).",
"URL": null,
"raw_pages": "371-6",
"medline_journal": "Nat Genet",
"ISO_journal": "Nat Genet",
"authors": [
"Pajukanta P",
"Lilja HE",
"Sinsheimer JS",
"Cantor RM",
"Lusis AJ",
"Gentile M",
"Duan XJ",
"Soro-Paavonen A",
"Naukkarinen J",
"Saarela J",
"Laakso M",
"Ehnholm C",
"Taskinen MR",
"Peltonen L."
],
"DOI_URL": null
},
"PUB00144529": {
"PMID": 2249772,
"ISBN": null,
"volume": "4",
"issue": "10",
"year": 1990,
"title": "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.",
"URL": null,
"raw_pages": "1730-40",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Gregor PD",
"Sawadogo M",
"Roeder RG."
],
"DOI_URL": null
},
"PUB00144531": {
"PMID": 20694678,
"ISBN": null,
"volume": "647",
"issue": null,
"year": 2010,
"title": "In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes.",
"URL": null,
"raw_pages": "339-55",
"medline_journal": "Methods Mol Biol",
"ISO_journal": "Methods Mol Biol",
"authors": [
"Galibert MD",
"Corre S."
],
"DOI_URL": null
},
"PUB00144532": {
"PMID": 22291606,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2012,
"title": "USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions.",
"URL": null,
"raw_pages": "e1002470",
"medline_journal": "PLoS Genet",
"ISO_journal": "PLoS Genet",
"authors": [
"Baron Y",
"Corre S",
"Mouchet N",
"Vaulont S",
"Prince S",
"Galibert MD."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl00081",
"name": "bHLH_SF"
},
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"bfvd": 0
},
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"taxa": 1358
},
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"is_llm": false,
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}
}
