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{
"metadata": {
"accession": "cd18324",
"entry_id": null,
"type": "domain",
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"source_database": "cdd",
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"integrated": null,
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"name": {
"name": "BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)",
"short": "BTB_POZ_ZBTB18_RP58"
},
"description": [
{
"text": "<p>ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. [[cite:PUB00139281], [cite:PUB00139282], [cite:PUB00139283], [cite:PUB00139284]]</p>",
"llm": false,
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"literature": {
"PUB00139284": {
"PMID": 24193349,
"ISBN": null,
"volume": "22",
"issue": "6",
"year": 2014,
"title": "A de novo non-sense mutation in ZBTB18 in a patient with features of the 1q43q44 microdeletion syndrome.",
"URL": null,
"raw_pages": "844-6",
"medline_journal": "Eur J Hum Genet",
"ISO_journal": "Eur J Hum Genet",
"authors": [
"de Munnik SA",
"Garcia-Minaur S",
"Hoischen A",
"van Bon BW",
"Boycott KM",
"Schoots J",
"Hoefsloot LH",
"Knoers NV",
"Bongers EM",
"Brunner HG."
],
"DOI_URL": null
},
"PUB00139282": {
"PMID": 9756912,
"ISBN": null,
"volume": "273",
"issue": "41",
"year": 1998,
"title": "RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression.",
"URL": null,
"raw_pages": "26698-704",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Aoki K",
"Meng G",
"Suzuki K",
"Takashi T",
"Kameoka Y",
"Nakahara K",
"Ishida R",
"Kasai M."
],
"DOI_URL": null
},
"PUB00139283": {
"PMID": 10721697,
"ISBN": null,
"volume": "242",
"issue": "1-2",
"year": 2000,
"title": "Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin.",
"URL": null,
"raw_pages": "59-64",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Meng G",
"Inazawa J",
"Ishida R",
"Tokura K",
"Nakahara K",
"Aoki K",
"Kasai M."
],
"DOI_URL": null
},
"PUB00139281": {
"PMID": 7633419,
"ISBN": null,
"volume": "4",
"issue": "4",
"year": 1995,
"title": "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain.",
"URL": null,
"raw_pages": "685-91",
"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum Mol Genet",
"authors": [
"Becker KG",
"Nagle JW",
"Canning RD",
"Biddison WE",
"Ozato K",
"Drew PD."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl38908",
"name": "BTB_POZ"
},
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"matches": 1023,
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"proteins": 1023,
"proteomes": 679,
"sets": 1,
"structural_models": {
"alphafold": 944,
"bfvd": 0
},
"structures": 1,
"taxa": 2093
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
