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{
    "metadata": {
        "accession": "cd18293",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18)",
            "short": "BTB_POZ_BTBD18"
        },
        "description": [
            {
                "text": "<p>BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids. [[cite:PUB00093489], [cite:PUB00144860]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00093489": {
                "PMID": 28292424,
                "ISBN": null,
                "volume": "40",
                "issue": "5",
                "year": 2017,
                "title": "BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice.",
                "URL": null,
                "raw_pages": "453-466.e5",
                "medline_journal": "Dev Cell",
                "ISO_journal": "Dev. Cell",
                "authors": [
                    "Zhou L",
                    "Canagarajah B",
                    "Zhao Y",
                    "Baibakov B",
                    "Tokuhiro K",
                    "Maric D",
                    "Dean J."
                ],
                "DOI_URL": null
            },
            "PUB00144860": {
                "PMID": 20598370,
                "ISBN": null,
                "volume": "34",
                "issue": "11",
                "year": 2010,
                "title": "BTBD18: A novel MLL partner gene in an infant with acute lymphoblastic leukemia and inv(11)(q13;q23).",
                "URL": null,
                "raw_pages": "e294-6",
                "medline_journal": "Leuk Res",
                "ISO_journal": "Leuk Res",
                "authors": [
                    "Alonso CN",
                    "Meyer C",
                    "Gallego MS",
                    "Rossi JG",
                    "Mansini AP",
                    "Rubio PL",
                    "Medina A",
                    "Marschalek R",
                    "Felice MS."
                ],
                "DOI_URL": null
            }
        },
        "set_info": {
            "accession": "cl38908",
            "name": "BTB_POZ"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 219,
            "pathways": 0,
            "proteins": 219,
            "proteomes": 184,
            "sets": 1,
            "structural_models": {
                "alphafold": 193,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 644
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}