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{
"metadata": {
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"type": "domain",
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"source_database": "cdd",
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"name": {
"name": "BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso",
"short": "BTB_POZ_ZBTB33_KAISO"
},
"description": [
{
"text": "<p>Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. [[cite:PUB00057813], [cite:PUB00141740], [cite:PUB00141741], [cite:PUB00141742], [cite:PUB00141743], [cite:PUB00077027], [cite:PUB00141120], [cite:PUB00141744], [cite:PUB00141745], [cite:PUB00141746]]</p>",
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"PMID": 14699141,
"ISBN": null,
"volume": "279",
"issue": "12",
"year": 2004,
"title": "Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells.",
"URL": null,
"raw_pages": "11417-24",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Kondapalli J",
"Flozak AS",
"Albuquerque ML."
],
"DOI_URL": null
},
"PUB00141742": {
"PMID": 15548582,
"ISBN": null,
"volume": "131",
"issue": "24",
"year": 2004,
"title": "Kaiso is a genome-wide repressor of transcription that is essential for amphibian development.",
"URL": null,
"raw_pages": "6185-94",
"medline_journal": "Development",
"ISO_journal": "Development",
"authors": [
"Ruzov A",
"Dunican DS",
"Prokhortchouk A",
"Pennings S",
"Stancheva I",
"Prokhortchouk E",
"Meehan RR."
],
"DOI_URL": null
},
"PUB00141746": {
"PMID": 15564377,
"ISBN": null,
"volume": "117",
"issue": "Pt 25",
"year": 2004,
"title": "Nuclear import of the BTB/POZ transcriptional regulator Kaiso.",
"URL": null,
"raw_pages": "6143-52",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Kelly KF",
"Otchere AA",
"Graham M",
"Daniel JM."
],
"DOI_URL": null
},
"PUB00141744": {
"PMID": 15817151,
"ISBN": null,
"volume": "305",
"issue": "2",
"year": 2005,
"title": "The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin.",
"URL": null,
"raw_pages": "253-65",
"medline_journal": "Exp Cell Res",
"ISO_journal": "Exp Cell Res",
"authors": [
"Spring CM",
"Kelly KF",
"O'Kelly I",
"Graham M",
"Crawford HC",
"Daniel JM."
],
"DOI_URL": null
},
"PUB00057813": {
"PMID": 10207085,
"ISBN": null,
"volume": "19",
"issue": "5",
"year": 1999,
"title": "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor.",
"URL": null,
"raw_pages": "3614-23",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Daniel JM",
"Reynolds AB."
],
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},
"PUB00141745": {
"PMID": 15781635,
"ISBN": null,
"volume": "65",
"issue": "6",
"year": 2005,
"title": "Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment.",
"URL": null,
"raw_pages": "2224-33",
"medline_journal": "Cancer Res",
"ISO_journal": "Cancer Res",
"authors": [
"Soubry A",
"van Hengel J",
"Parthoens E",
"Colpaert C",
"Van Marck E",
"Waltregny D",
"Reynolds AB",
"van Roy F."
],
"DOI_URL": null
},
"PUB00141740": {
"PMID": 11445535,
"ISBN": null,
"volume": "15",
"issue": "13",
"year": 2001,
"title": "The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor.",
"URL": null,
"raw_pages": "1613-8",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Prokhortchouk A",
"Hendrich B",
"Jorgensen H",
"Ruzov A",
"Wilm M",
"Georgiev G",
"Bird A",
"Prokhortchouk E."
],
"DOI_URL": null
},
"PUB00141741": {
"PMID": 14527417,
"ISBN": null,
"volume": "12",
"issue": "3",
"year": 2003,
"title": "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.",
"URL": null,
"raw_pages": "723-34",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol Cell",
"authors": [
"Yoon HG",
"Chan DW",
"Reynolds AB",
"Qin J",
"Wong J."
],
"DOI_URL": null
},
"PUB00141120": {
"PMID": 16354688,
"ISBN": null,
"volume": "26",
"issue": "1",
"year": 2006,
"title": "A family of human zinc finger proteins that bind methylated DNA and repress transcription.",
"URL": null,
"raw_pages": "169-81",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Filion GJ",
"Zhenilo S",
"Salozhin S",
"Yamada D",
"Prokhortchouk E",
"Defossez PA."
],
"DOI_URL": null
},
"PUB00077027": {
"PMID": 23251453,
"ISBN": null,
"volume": "7",
"issue": "12",
"year": 2012,
"title": "Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.",
"URL": null,
"raw_pages": "e51205",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Barrett CW",
"Smith JJ",
"Lu LC",
"Markham N",
"Stengel KR",
"Short SP",
"Zhang B",
"Hunt AA",
"Fingleton BM",
"Carnahan RH",
"Engel ME",
"Chen X",
"Beauchamp RD",
"Wilson KT",
"Hiebert SW",
"Reynolds AB",
"Williams CS."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0051205"
}
},
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"name": "BTB_POZ"
},
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"taxa": 1998
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}
